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Article (Scientific journals)
Interim results on the clinical effects of i.v. administered thymopentin in active rheumatoid arthritis
Malaise, Michel; Franchimont, P.; Hauwaert, Christian et al.
1984In International Journal of Clinical Pharmacology, Therapy and Toxicology, 4 (6), p. 451-457
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Keywords :
thymopentin; placebo; rheumatoid arthritis
Abstract :
[en] Forty-one patients with active rheumatoid arthritis entered a controlled, double-blind, randomized study; 21 received prolonged i.v. injections (10 min) of thymopentin 50 mg 3 times a week for 3 consecutive weeks; the other 20 received placebo under the same conditions. The groups were comparable at the start of the study. Statistical tests of changes within the treatment groups after 3 weeks showed that the improvement achieved in the thymopentin group was significant (p less than 0.05 or p less than 0.01) for each clinical parameter, except for left-hand grip strength. On the other hand, no significant improvement was observed for any parameter except morning stiffness in the patients on placebo. The intergroup comparison showed significant differences, favouring thymopentin over placebo treatment, in the Ritchie index, scores for swollen joints, assessment of severity of pain and scores for changes in the activity of the disease. Only minor side-effects were experienced in the two treatment groups. The present placebo-controlled double-blind study confirms the previous positive results achieved in open studies, i.e., the beneficial therapeutic effect of prolonged i.v. injections of thymopentin in patients with severe rheumatoid arthritis observed after 3 weeks of therapy. The drug appears to be safe at the dose regimen used.
Disciplines :
Rheumatology
Author, co-author :
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Franchimont, P.
Hauwaert, Christian ;  Université de Liège - ULiège > Rhumatologie
Danneskiold-Samsoe, B.
Gross, D.
Gerber, H.
Gerschpacher, H.
Bolla, K.
Language :
English
Title :
Interim results on the clinical effects of i.v. administered thymopentin in active rheumatoid arthritis
Publication date :
1984
Journal title :
International Journal of Clinical Pharmacology, Therapy and Toxicology
ISSN :
0300-9718
Publisher :
Urban und Schwarzenberg, Munchen, Germany
Volume :
4
Issue :
6
Pages :
451-457
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2011

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