Article (Scientific journals)
Measurement of proteoglycans, elastase, collagenase and protein in synovial fluid in inflammatory and degenerative arthropathies
Gysen, Philippe; Malaise, Michel; Gaspar, S. et al.
1985In Clinical Rheumatology, 4 (1), p. 39-50
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Keywords :
Elastase; Vertebrate Collagenase; Human Cartilage Proteoglycans; Osteoarthritis; Rheumatoid Arthritis
Abstract :
[en] The number of leucocytes and the concentrations of protein, proteoglycans (PG), elastase a1 proteinase inhibitor complexes and collagenolytic activity were measured in the synovial fluid (SF) of 15 patients with rheumatoid arthritis (RA) and 18 with osteoarthritis (OA). The mean levels of protein and collagenase and the number of leucocytes were higher in RA than in OA SF. However, the mean level of PG was higher of OA SF than in RA. In the latter, they were principally in the form of monomers and fragments while in the former they were in the form of aggregates and monomers. There was a direct relationship between the concentration of E-a/Pi and either the number of white cells or the concentration of synovial proteins, suggesting that the measurement of E-a/Pi complexes is a biochemical index of the local inflammatory reaction. There was an inverse correlation between the concentrations ofPG and E-a/Pi which may reflect the effect of degradation in PG of elastase and other enzymes released at the same time. Finally, there was a direct relationship between the concentration of E-a/Pi and collagenase which may be the reflection of a simultaneous release of various enzymes from leucocytes and macrophages.
Disciplines :
Rheumatology
Author, co-author :
Gysen, Philippe ;  Université de Liège - ULiège
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Gaspar, S.
Franchimont, Paul ;  Université de Liège - ULiège
Language :
English
Title :
Measurement of proteoglycans, elastase, collagenase and protein in synovial fluid in inflammatory and degenerative arthropathies
Publication date :
1985
Journal title :
Clinical Rheumatology
ISSN :
0770-3198
eISSN :
1434-9949
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
4
Issue :
1
Pages :
39-50
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2011

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