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Elevated antigalactosyl antibody titers reflect renal injury after gold or D-penicillamine in rheumatoid arthritis
Malaise, Michel; Davin, J. C.; Mahieu, P. R. et al.
1986In Clinical Immunology and Immunopathology, 40 (2), p. 356-364
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Keywords :
Immunoglobulin G; Organogold Compounds; Organometallic Compounds; Dimercaprol; aurotioprol; Penicillamine
Abstract :
[en] Titers of circulating antigalactosyl antibodies (a-Gal Ab) were assessed by passive hemagglutination using rabbit red blood cells in 40 normal subjects, in 14 patients with immunodeficient states, in 47 patients with active rheumatoid arthritis (RA), and in 15 patients with an Henoch-Schonlein disease (HS). Titers of controls ranged from 1:16 to 1:64. All immunodeficient patients exhibited very low titers (1:1). On the contrary, the existence of an enhanced humoral immune response status, as observed in RA, was not reflected by a parallel increase of a-Gal Ab titers. However, in this disease, a strong relationship existed between titers exceeding control values (greater than 1:64) and the prior occurrence of renal injury under gold or D-penicillamine therapy. Lastly, the discovery of elevated titers (greater than 1:64) in HS only when renal involvement occurred further suggests that such antibodies reflect a renal injury.
Disciplines :
Rheumatology
Author, co-author :
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Davin, J. C.
Mahieu, P. R.
Franchimont, P.
Language :
English
Title :
Elevated antigalactosyl antibody titers reflect renal injury after gold or D-penicillamine in rheumatoid arthritis
Publication date :
1986
Journal title :
Clinical Immunology and Immunopathology
ISSN :
0090-1229
Publisher :
Academic Press, Orlando, United States - Florida
Volume :
40
Issue :
2
Pages :
356-364
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2011

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