[en] The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schonlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P < 0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.
Disciplines :
Rheumatology
Author, co-author :
Davin, J. C.
Pierard, Gérald ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Dechenne, Charles ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Grossman, D.
Nagy, J.
Quacoe, M.
Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Hall, M.
Jansen, F.
Chantraine, J. M.
Language :
English
Title :
Possible pathogenic role of IgE in Henoch-Schonlein purpura
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