Article (Scientific journals)
Comment je traite ... la leucemie myeloide chronique (LMC).
Hafraoui, Kaoutar; Humblet-Baron, Stéphanie; Baron, Frédéric et al.
2003In Revue Médicale de Liège, 58 (1), p. 7-12
Peer reviewed
 

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Keywords :
Algorithms; Antimetabolites, Antineoplastic/therapeutic use; Antineoplastic Agents/therapeutic use; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine/therapeutic use; Enzyme Inhibitors/therapeutic use; Fusion Proteins, bcr-abl/antagonists & inhibitors; Hematopoietic Stem Cell Transplantation; Humans; Interferon-alpha/therapeutic use; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy; Piperazines/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrimidines/therapeutic use
Abstract :
[en] This review article describes the identification of the tyrosine kinase BCR/ABL as the hallmark of chronic myeloid leukemias (CML) as well as the development of a specific inhibitor of this tyrosine kinase, the STI571 (Glivec, imatinib mesylate). The authors discuss the results of a phase I and three phase II trials reporting the efficacy of STI571 as treatment for CML patients and propose two simplified algorithms that may help to guide decision-making for the individual patient.
Disciplines :
Hematology
Author, co-author :
Hafraoui, Kaoutar ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Humblet-Baron, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie CHR
Baron, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
French
Title :
Comment je traite ... la leucemie myeloide chronique (LMC).
Alternative titles :
[en] How I treat...chronic myeloid leukemia
Publication date :
2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
58
Issue :
1
Pages :
7-12
Peer reviewed :
Peer reviewed
Available on ORBi :
since 23 March 2009

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