Reference : Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritid...
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/94581
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not
English
Ribbens, Clio mailto [Université de Liège - ULg > > Rhumatologie >]
Andre, Béatrice mailto [Université de Liège - ULg > > Rhumatologie - Néphrologie >]
Kaye, O. [ > > ]
Kaiser, M. J. [ > > ]
Bonnet, V. [ > > ]
Jaspar, J. M. [ > > ]
de Groote, D. [ > > ]
Franchimont, N. [ > > ]
Malaise, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
2000
Rheumatology
Oxford University Press
39
12
1357-1365
Yes (verified by ORBi)
International
1462-0324
1462-0332
Oxford
United Kingdom
[en] Biological Markers ; Fibrinogen ; C-Reactive Protein ; Rheumatoid Arthritis ; Matrix Metalloproteinase 3
[en] OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee
synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether
erosive or not, reactive arthritis, acute crystal arthritis) and degenerative
arthropathies [chronic crystal disease, osteoarthritis and (control) meniscus
pathology] and to correlate them with the degree of joint destruction, local
inflammatory and immune parameters and systemic markers of inflammation. METHODS:
SF levels of MMP-3 (precursor, active and tissue inhibitor of MMP-bound forms),
tumour necrosis factor (TNF) alpha, soluble TNF receptors I and II, interleukin
(IL)-6 and soluble IL-6 receptor were measured by ELISA in 107 inflammatory and
53 degenerative arthropathies. RESULTS: MMP-3 levels in SF were (i) significantly
higher in inflammatory than in degenerative arthropathies; (ii) not related to
the degree of joint destruction; (iii) significantly correlated with the levels
of all SF markers tested and with erythrocyte sedimentation rate and serum levels
of C-reactive protein and fibrinogen. CONCLUSION: Increased MMP-3 levels in SF
are found in inflammatory arthropathies and are not specific for erosive joint
diseases. MMP-3 in SF is therefore a potential candidate for the assessment of
the inflammatory process in joints. However, the exclusive determination of the
active form could indicate the degree of joint destruction.
Researchers ; Professionals
http://hdl.handle.net/2268/94581

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