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La stromelysine-1 en pathologie inflammatoire: signification, specificite et elements de regulation
Ribbens, Clio; Malaise, Michel
2001In Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 156 (5-6), p. 275-281, discussion 281-283
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Keywords :
cytokines; Arthritis
Abstract :
[en] Stromelysin-1 or matrix metalloproteinase-3 (MMP-3) is a key enzyme of the degradation of the extracellular matrix in rheumatoid arthritis. MMP-3 is indeed induced by pro-inflammatory cytokines and may in turn activate other metalloproteinases. MMP-3 is a synovial parameter reflecting the local inflammatory reaction induced by inflammatory cytokines. It is not specific for rheumatoid arthritis nor for the erosive capacity of an arthropathy, which does not exclude its role in articular degradation. Serum MMP-3 is increased in diseases characterized by synovitis but also by steroid therapy. Although it is not disease-specific, serum MMP-3 could be useful as a synovial-derived marker of local inflammation in rheumatoid arthritis, in parallel to CRP which is a systemic marker of inflammation. Furthermore, early determination of serum MMP-3 could constitute a new tool predictive of the disease activity and the therapeutic response in rheumatoid arthritis.
Disciplines :
Rheumatology
Author, co-author :
Ribbens, Clio ;  Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Language :
French
Title :
La stromelysine-1 en pathologie inflammatoire: signification, specificite et elements de regulation
Alternative titles :
[en] stromelysin-1 in inflammatory disease: significance, specificity, and regulation elements
Publication date :
2001
Journal title :
Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique
ISSN :
0377-8231
Publisher :
Académie Royale de Médecine de Belgique, Bruxelles, Belgium
Volume :
156
Issue :
5-6
Pages :
275-281, discussion 281-283
Peer reviewed :
Peer Reviewed verified by ORBi
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