Reference : Early detection of relapse by whole-body positron emission tomography in the follow-up o...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/9457
Early detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin's disease.
English
Jerusalem, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Fassotte, Marie-France mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Belhocine, T. [> > > >]
Hustinx, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Rigo, Pierre mailto [Université de Liège - ULg > Département des sciences de la motricité > Pathologie générale et médecine nucléaire >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2003
Annals of Oncology
Oxford University Press
14
1
123-30
Yes (verified by ORBi)
International
0923-7534
1569-8041
London
United Kingdom
[en] Adolescent ; Adult ; Aged ; False Negative Reactions ; Female ; Fluorodeoxyglucose F18/diagnostic use ; Follow-Up Studies ; Hodgkin Disease/metabolism/radionuclide imaging/therapy ; Humans ; L-Lactate Dehydrogenase/metabolism ; Male ; Middle Aged ; Neoplasm Recurrence, Local/radionuclide imaging ; Neoplasm Staging ; Neoplasm, Residual/radionuclide imaging ; Prospective Studies ; Radiopharmaceuticals/diagnostic use ; Thymus Gland/radionuclide imaging ; Tomography, Emission-Computed ; Tomography, X-Ray Computed
[en] BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron emission tomography (PET) for the detection of preclinical relapse. PATIENTS AND METHODS: Thirty-six patients underwent 2-[fluorine-18]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET at the end of treatment and than every 4-6 months for 2-3 years after the end of polychemotherapy and/or radiotherapy. In those cases of abnormal (18)F-FDG accumulation a confirmatory study was performed 4-6 weeks later. RESULTS: One patient had residual tumor and four patients relapsed during a follow-up of 5-24 months. All five events were correctly identified early by (18)F-FDG PET. Residual tumor or relapse was never first diagnosed based on clinical examination, laboratory findings or computed tomography (CT) studies. Two patients presented B symptoms and the three others were asymptomatic at the time of residual disease or relapse. Confirmation of residual disease or relapse was obtained by biopsy in four patients 1, 1, 5 and 9 months after PET and by unequivocal clinical symptoms and CT studies in one patient 3 months after PET. False-positive (18)F-FDG PET studies incorrectly suggested possible relapse in six other patients, but the confirmatory PET was always negative. Our study also provides important information about physiological (18)F-FDG uptake in the thymus. CONCLUSIONS: Our data suggest the potential of (18)F-FDG PET to detect preclinical relapse in patients with HD. This could help identify patients requiring salvage chemotherapy at the time of minimal disease rather than at the time of clinically overt relapse. Further studies are warranted to determine the impact of PET on treatment management and outcome. In fact, the aim of follow-up procedures is not only to detect preclinical relapse but mainly to obtain better results by starting salvage treatment earlier. A cost-benefit analysis will also be necessary before (18)F-FDG PET can be used routinely in the follow-up of patients with HD.
http://hdl.handle.net/2268/9457

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
180.pdfPublisher postprint321.74 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.