Article (Scientific journals)
Interleukin-6: An osteotropic factor influencing bone formation?
Franchimont, N.; Wertz, Sylvie; Malaise, Michel
2005In BONE, 37 (5), p. 601-606
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Keywords :
interleukin-6; Bone formation; Bone Resorption/physiopathology; Cell Differentiation; Cell Proliferation; Humans; Interleukin-6/physiology; Leptin/physiology; Osteoblasts/cytology/pathology/physiology; Osteogenesis/physiology; Receptors, Interleukin-6/physiology; Signal Transduction
Abstract :
[en] Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted. (c) 2005 Elsevier Inc. All rights reserved.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Franchimont, N.
Wertz, Sylvie ;  Université de Liège - ULiège > Gastro-Entérologie-Hépatologie
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Language :
English
Title :
Interleukin-6: An osteotropic factor influencing bone formation?
Publication date :
November 2005
Journal title :
BONE
ISSN :
8756-3282
eISSN :
1873-2763
Publisher :
Elsevier Science, New York, United States - New York
Volume :
37
Issue :
5
Pages :
601-606
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2011

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