|Reference : Laminin promotes cerebellar granule cells migration in vitro and is synthesized by cultu...|
|Scientific journals : Article|
|Life sciences : Biochemistry, biophysics & molecular biology|
Human health sciences : Neurology
|Laminin promotes cerebellar granule cells migration in vitro and is synthesized by cultured astrocytes|
|SELAK, Ivan [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]|
|Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]|
|Moonen, Gustave [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]|
|Yes (verified by ORBi)|
|[en] Newborn rat cerebellum microexplants have been used as a model to study neuronal migration. Laminin in a substrate-bound form modifies extensively the migratory behavior of the neurones, an effect which is blocked if antilaminin antibodies are present during the assay. 35S methionine incorporation followed by SDS-PAGE electrophoresis, fluorography and immunoprecipitation with antilaminin antibodies allowed to demonstrate that laminin is synthesized and secreted by cultured newborn rat cerebellum as well as by cultured newborn rat cerebral cortex astrocytes.|
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