Reference : Peripheral blood progenitor cell collections in cancer patients: analysis of factors ...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/9442
Peripheral blood progenitor cell collections in cancer patients: analysis of factors affecting the yields.
English
Sautois, Brieuc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Fraipont, V. [> > > >]
Baudoux, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire >]
Fassotte, Marie-France mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Hermanne, J. P. [> > > >]
Jerusalem, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Bours, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Bosquee, Léon mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Schaaf-Lafontaine, Nicole mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Paulus, Jean-Michel mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Sondag, Danièle mailto [Université de Liège - ULg > Département des sciences de la santé publique > Immunohématologie - Transfusion >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
1999
Haematologica
Ferrata Storti Foundation
84
4
342-9
Yes (verified by ORBi)
International
0390-6078
1592-8721
Pavia
Italy
[en] Adolescent ; Adult ; Aged ; Antigens, CD34 ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Blood Cell Count ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Granulocyte Colony-Stimulating Factor/pharmacology ; Hematologic Neoplasms/pathology/therapy ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/pathology ; Humans ; Leukapheresis ; Male ; Middle Aged ; Neoplasms/pathology/therapy ; Predictive Value of Tests ; Transplantation, Autologous
[en] BACKGROUND AND OBJECTIVE: Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies. We sought to identify parameters that could predict the yield of PBPC after mobilization with chemotherapy (CT) with or without granulocyte colony-stimulating factor (G-CSF) in cancer patients. DESIGN AND METHODS: One hundred and fifty patients underwent 627 PBPC collections during the recovery phase following CT with (n = 469) or without (n = 142) G-CSF. Hemogram, CFC-assays and CD34+ cell count were performed on peripheral blood and leukaphereses products. After log transformation of the data, differences between groups were assessed with the unpaired t-test or one-way analysis of variance. RESULTS: Seventeen and two patients required 2 and 3 mobilization cycles respectively to reach our target of 15x10(4) CFU-GM/kg. In patients with lymphoma but not in those with leukemia, the yields of both CFU-GM and CD34+ cells/kg were dramatically increased when G-CSF was added to CT for mobilization. In collections primed with CT and G-CSF, better yields were obtained in patients with breast cancer or small-cell lung carcinoma (SCLC) as opposed to other solid tumors and leukemia. Among potential predictive factors of CT- and G-CSF-primed harvests, we found that the CD34+ cell count in peripheral blood (PB) was strongly correlated with both the CFU-GM and CD34+ cell yields. Except in leukemia patients, more than 1x10(6) CD34+ cells/kg were harvested when the CD34+ cell count in blood was above 20x10(6)/L. Similarly, better results were obtained in collections performed when the percentage of myeloid progenitors in blood on the day of apheresis was above 5 % or when the leukocyte count in blood was above 5x10(9)/L. INTERPRETATION AND CONCLUSIONS: A diagnosis of breast cancer or SCLC, a leukocyte count in PB of more than 5x10(9)/L, more than 5% myeloid progenitors or more than 20x10(6) CD34+ cells/L in PB were associated with higher yields of PBPC in collections mobilized with CT+G-CSF.
http://hdl.handle.net/2268/9442

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