Reference : Myasthenia gravis without chronic GVHD after allogeneic bone marrow transplantation.
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/9441
Myasthenia gravis without chronic GVHD after allogeneic bone marrow transplantation.
English
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Sadzot, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Wang, François-Charles mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
1998
Bone Marrow Transplantation
Nature Publishing Group
22
2
197-200
Yes (verified by ORBi)
International
0268-3369
London
United Kingdom
[en] Adult ; Anemia, Aplastic/therapy ; Bone Marrow Transplantation/adverse effects ; Graft vs Host Disease/etiology/immunology ; Humans ; Male ; Myasthenia Gravis/etiology/immunology ; Transplantation, Homologous
[en] A 20-year-old man with aplastic anemia developed myasthenia gravis (MG) 7 months after bone marrow transplantation (BMT) from an HLA one locus-mismatched sister. Proximal muscle weakness (predominant in the lower limbs) and dysphagia occurred without any other sign of graft-versus-host disease (GVHD), 1 month after cessation of immunosuppression with cyclosporine. The diagnosis of MG was based on clinical symptoms and on neurophysiologic investigations showing a significant increase of the Jitter in single-fiber electromyography and a significant decremental response during repetitive stimulation at slow rates, but antibodies against the acetylcholine receptor (AchRab) were negative. All clinical and neurophysiological signs normalized within 1 month of treatment with low-dose prednisolone and pyridostigmine, and the patient is perfectly well 1 year after cessation of all therapy. All cases of BMT-associated MG previously published are reviewed in comparison with ours. The originality of this new observation is that this case is the only one not associated with chronic GVHD and negative for AchRab. Alternatively, MG may have been the sole manifestation of chronic GVHD in this patient.
http://hdl.handle.net/2268/9441
10.1038/sj.bmt.1701297

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