Reference : Bronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bo...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/9440
Bronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation.
English
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Hermanne, Jean-Philippe [Centre Hospitalier Universitaire de Liège - CHU >]
Dowlati, A. [> > > >]
Weber, T. [> > > >]
Thiry, Albert mailto [Université de Liège - ULg > > Anatomie pathologique >]
Fassotte, Marie-France mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
1998
Bone Marrow Transplantation
Nature Publishing Group
21
9
951-4
Yes (verified by ORBi)
International
0268-3369
London
United Kingdom
[en] Adoptive Transfer ; Adult ; Autoimmunity ; Bone Marrow Transplantation/adverse effects ; Colitis, Ulcerative/drug therapy/etiology/immunology ; Crohn Disease/immunology ; Cryptogenic Organizing Pneumonia/drug therapy/etiology/immunology ; HLA Antigens ; Humans ; Leukemia, Myeloid, Acute/therapy ; Male ; Methylprednisolone/therapeutic use ; Tissue Donors ; Transplantation, Homologous
[en] A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT) from an HLA-matched brother who suffered from severe Crohn's disease. BOOP occurred 20 days after idiopathic interstitial pneumonia, in the context of severe ulcerative colitis. Lung and colon biopsies showed no signs of CMV infection or GVHD. The patient was treated with oral methylprednisolone 1 mg/kg/day and his clinical status and chest X-ray improved slowly. Remarkably, the symptoms of colitis also resolved with prednisone therapy and he is now symptom-free. We hypothesize that ulcerative colitis may have been transmitted from donor to recipient (adoptive autoimmunity) and that it was complicated by BOOP. However, other factors such as CMV may have contributed to the occurrence of BOOP.
http://hdl.handle.net/2268/9440
10.1038/sj.bmt.1701198

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