Article (Scientific journals)
Serum concentration of surfactant protein D in horses with lower airway inflammation
Richard, Eric; Pitel, Pierre-Hugues; Christmann, Undine et al.
2012In Equine Veterinary Journal, 44, p. 277–281
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Keywords :
horse; surfactant protein D; biomarker; inflammatory airway disease; exercise
Abstract :
[en] Reasons for performing study: Surfactant protein D (SP-D), mainly synthesised by alveolar type II cells and nonciliated bronchiolar cells, is one important component of innate pulmonary immunity. In man, circulating concentrations of SP-D are routinely used as biomarkers for pulmonary injury. To date, serum SP-D levels have only been investigated in horses in an experimental model of bacterial airway infection. Objectives: To compare serum SP-D concentrations at rest and after exercise in horses with and without inflammatory airway disease (IAD). Methods: Venous blood samples were collected from 42 Standardbred racehorses at rest and 60 min after performing a standardised treadmill exercise test. Tracheal wash and bronchoalveolar lavage fluid (BALF) samples were collected after exercise. Based on BALF cytology, 22 horses were defined as IAD-affected and 20 classified as controls. Serum SP-D concentrations were assessed using a commercially available ELISA kit and statistically compared between groups of horses and sampling times. Results: Serum concentrations of SP-D in IAD-affected horses were significantly higher than those of control horses, both at rest and after exercise. Within the IAD-affected group, no significant correlation was found between serum SP-D concentrations and BALF cytology. Within each group of horses (IAD and control), no significant influence of exercise was found on serum SP-D levels. Conclusions: This is the first study determining serum SP-D concentrations in a noninfectious, naturally occurring form of lower airway inflammation in horses. The results highlight that IAD is associated with a detectable, though moderate, increase of circulating SP-D levels. Potential relevance: Serum concentration of surfactant protein D could represent a potentially valuable and readily accessible blood biomarker of equine lower airway inflammation
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Richard, Eric;  Frank Duncombe Laboratory
Pitel, Pierre-Hugues
Christmann, Undine
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Fortier, Guillaume
Pronost, Stéphane
Language :
English
Title :
Serum concentration of surfactant protein D in horses with lower airway inflammation
Publication date :
2012
Journal title :
Equine Veterinary Journal
ISSN :
0425-1644
eISSN :
2042-3306
Publisher :
Equine Veterinary Journal Ltd, Newmarket Suffolk, United Kingdom
Volume :
44
Pages :
277–281
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 June 2011

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