Reference : Catalytic activation of copper(II) salts on the reaction of peroxynitrite with propofol ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/940
Catalytic activation of copper(II) salts on the reaction of peroxynitrite with propofol in alkaline medium
English
Kohnen, Stephan mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Halusiak, Emilie [Université de Liège - ULg > > Centre d'études et de rech. sur les macromolécules (CERM) >]
Mouithys-Mickalad, Ange mailto [Université de Liège - ULg > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
Deby-Dupont, G. [> > > >]
Deby, Christiane [Centre Hospitalier Universitaire de Liège - CHU > > Administration des patients - Admission des hospitalisés >]
Hans, Pol [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Noels, A. F. [> > > >]
Jun-2005
Nitric Oxide
Academic Press Inc Elsevier Science
12
4
252-260
Yes (verified by ORBi)
International
1089-8603
San Diego
[en] catalysis ; copper ; nitration ; nitrosation ; peroxynitrite ; propofol
[en] We report here on the role of copper (II) salts on the acceleration of peroxynitrite (ONOO-) decomposition and ONOO- reaction with the anaesthetic agent propofol (2,6-diisopropylphenol) in alkaline medium. We observed a strong acceleration of the ONOO- decomposition in alkaline medium in the presence of copper (I and II) salts. After 18 h of ONOO- reaction with propofol, we observed nitrosated, nitrated, and oxidized (quinone and diphenylquinone) derivatives of propofol, but in the presence of Cu(II) (20% molar vs ONOO-), the yields of quinone and nitrosopropofol strongly increased. We also observed that the temperature and the atmosphere influenced the effects of Cu(II) on ONOO- reactions with propofol: low temperatures promoted nitrosation and high temperatures promoted oxidation; O-2 atmosphere increased the general reactivity and the yield of nitrated and oxidized products. We highlighted the influence of Cu(II) salts on the radical character of the reaction by direct EPR technique. The exact mechanism of the Cu(II) catalysis remains unexplained, but we suggest the formation of a copper complex with propofol or, more probably, the oxidation of ONOO- into ONOO• by copper ions promoting the formation of quinone and nitrosopropofol according to a previously reported mechanism [M. Cudic, C. Ducrocq, Transformations of 2,6-diisopropylphenol by NO-derived nitrogen oxides, particularly peroxyrutrite, Nitric Oxide 4 (2000) 147-156]. © 2005 Elsevier Inc. All rights reserved.
http://hdl.handle.net/2268/940
10.1016/j.niox.2005.03.003

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