Reference : 17-O-acetyl, 10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from S...

	Document type :	Scientific congresses and symposiums : Unpublished conference
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/93733

Title :	17-O-acetyl, 10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves
Language :	English
Author, co-author :	Cao, Martine [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Muganga, Raymond [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Publication date :	13-May-2011
On invitation :	No
Audience :	National
Event name :	15th Forum of Pharmaceutical Sciences
Event date :	du 12 mai 2011 au 13 mai 2011
Event organizer :	Belgian Society of Pharmaceutical Sciences
Event place (city) :	Spa
Event country :	Belgium
Abstract :	[en] In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl, 10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR and ESI-MS. 17-O-acetyl, 10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloid known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity.
Permalink :	http://hdl.handle.net/2268/93733

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