Reference : MT-MMPs as regulators of vessel stability associated with angiogenesis

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/93636

Title :	MT-MMPs as regulators of vessel stability associated with angiogenesis
Language :	English
Author, co-author :	Sounni, Nor Eddine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement > > >]
	Paye, Alexandra [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Host, Lorin [ > > ]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Publication date :	13-May-2011
Journal title :	Frontiers in Pharmacology of Anti-Cancer Drugs
Publisher :	Frontiers
Volume :	2:111
Audience :	International
City :	Lausanne
Country :	Switzerland
Keywords :	[en] MT-MMPs ; MMPs ; collagen ; vessel permeability ; interstitial fluid pressure
Abstract :	[en] The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evidence, point to a direct role of membrane type-MMPs (MT-MMPs) in vascular system stabilization, maturation, and leakage. Our understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell-ECM interactions and cell fate decisions in pathological conditions. Regulation of vascular leakage by MT-MMP interactions with the ECM could also lead to novel targeting opportunities for drug delivery in tumor. This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression.
Target :	Researchers ; Professionals ; Students ; Others
Permalink :	http://hdl.handle.net/2268/93636
DOI :	10.3389/fphar.2011.00111
Framework Programme / European Project :	FP7 ; 201279 - MICROENVIMET - Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network.

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