Reference : Metathesis access to monocyclic iminocyclitol-based therapeutic agents
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/93585
Metathesis access to monocyclic iminocyclitol-based therapeutic agents
English
Dragutan, Ileana [> > > >]
Dragutan, Valerian [> > > >]
Mitan, Carmen [> > > >]
Vosloo, Hermanus C M [> > > >]
Delaude, Lionel mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique]
Demonceau, Albert mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
2011
Beilstein Journal Of Organic Chemistry
Beilstein-Institut
7
699-716
Yes (verified by ORBi)
International
1860-5397
Frankfurt Am Main
Allemagne
[en] azasugars ; iminocyclitols ; natural products ; olefin metathesis ; Ru-alkylidene catalysts
[en] By focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine-and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted.
Researchers ; Professionals
http://hdl.handle.net/2268/93585
10.3762/bjoc.7.81

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