Reference : Immune suppression in head and neck cancers: a review.
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/93561
Immune suppression in head and neck cancers: a review.
English
Duray, Annaëlle mailto [> >]
Demoulin, Stéphanie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Hubert, Pascale mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Saussez, Sven [University of Mons > faculty of Medicine and Pharmacy > Laboratory of Anatomy > >]
2010
Clinical & Developmental Immunology
Hindawi Publishing Corporation
2010
701657
Yes (verified by ORBi)
International
1740-2522
1740-2530
[en] Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.
Giga-Cancer
http://hdl.handle.net/2268/93561
10.1155/2010/701657

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