Reference : Sex differences in adolescent depression: do sex hormones determine vulnerability?
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/93102
Sex differences in adolescent depression: do sex hormones determine vulnerability?
English
Naninck, E. F. G. [> > > >]
Lucassen, P. J. [> > > >]
Bakker, Julie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2011
Journal of Neuroendocrinology
Blackwell Publishing
23
5
383-92
Yes (verified by ORBi)
International
0953-8194
1365-2826
Oxford
United Kingdom
[en] hormones ; adolescence ; puberty ; sex differences ; depression ; fluoxetine
[en] Depression is one of the most common, costly and severe psychopathologies worldwide. Its incidence, however, differs significantly between the sexes, and depression rates in women are twice those of men. Interestingly, this sex difference emerges during adolescence. Although the adolescent period is characterised by major physical and behavioural transformations, it is unclear why the incidence of depression increases so dramatically in girls during this otherwise generally healthy developmental period. Although psychological and environmental factors are also involved, we discuss the neuroendocrinological factors determining adolescent vulnerability to depression. In particular, we address the role of sex steroids in mood regulation, hypothalamic-pituitary-adrenal axis maturation and sexual differentiation of the brain, with a focus on hippocampal plasticity.
Researchers
http://hdl.handle.net/2268/93102
10.1111/j.1365-2826.2011.02125.x
(c) 2011 The Authors. Journal of Neuroendocrinology (c) 2011 Blackwell Publishing Ltd.

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