Article (Scientific journals)
Feedback control strategies for spatial navigation revealed by dynamic modelling of learning in the Morris water maze
Fey, Dirk; Commins, Sean; Bullinger, Eric
2011In Journal of Computational Neuroscience, 30 (2), p. 447-454
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Abstract :
[en] The Morris water maze is an experimental procedure in which animals learn to escape swimming in a pool using environmental cues. Despite its success in neuroscience and psychology for studying spatial learning and memory, the exact mnemonic and navigational demands of the task are not well understood. Here, we provide a mathematical model of rat swimming dynamics on a behavioural level. The model consists of a random walk, a heading change and a feedback control component in which learning is reflected in parameter changes of the feedback mechanism. The simplicity of the model renders it accessible and useful for analysis of experiments in which swimming paths are recorded. Here, we used the model to analyse an experiment in which rats were trained to find the platform with either three or one extramaze cue. Results indicate that the 3-cues group employs stronger feedback relying only on the actual visual input, whereas the 1-cue group employs weaker feedback relying to some extent on memory. Because the model parameters are linked to neurological processes, identifying different parameter values suggests the activation of different neuronal pathways.
Research center :
Giga-Systems Biology and Chemical Biology - ULiège
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Fey, Dirk ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation : Méth. computat. pour la bio.syst.
Commins, Sean
Bullinger, Eric 
Language :
English
Title :
Feedback control strategies for spatial navigation revealed by dynamic modelling of learning in the Morris water maze
Publication date :
2011
Journal title :
Journal of Computational Neuroscience
ISSN :
0929-5313
eISSN :
1573-6873
Publisher :
Kluwer Academic Publishers, Boston, United States - Massachusetts
Volume :
30
Issue :
2
Pages :
447-454
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 June 2011

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