Reference : Descriptive study of 32 cases of doxycycline-overdosed calves.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/92834
Descriptive study of 32 cases of doxycycline-overdosed calves.
English
[en] Etude descriptive de 32 cas de surdosage à la doxycycline chez des veaux.
Brihoum, Mounir mailto [Université de Liège - ULg > > > Doct. sc. vété. (Bologne)]
Amory, Hélène mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Cassart, Dominique mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie >]
Deleuze, Stefan mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Obstét. et path. de la reprod. des anim. de comp. et équidés >]
Rollin, Frédéric mailto [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs >]
2010
Journal of Veterinary Internal Medicine
Allen Press
24
5
1203-10
Yes (verified by ORBi)
International
0891-6640
Lawrence
KS
[en] Animals ; Anti-Bacterial Agents/administration & dosage/adverse effects ; Cardiology ; Cattle ; Cattle Diseases/chemically induced/mortality ; Doxycycline/administration & dosage/adverse effects ; Kidneys ; Liver ; Muscle, Skeletal/pathology ; Myocardium/pathology ; Overdose ; Retrospective Studies ; Tongue/pathology ; Toxicity
[en] BACKGROUND: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves.
OBJECTIVE: To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously.
ANIMALS: Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders.
METHOD: Retrospective review of medical records.
RESULTS: Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver.
CONCLUSIONS: Most of these findings corroborate previous observations made in doxycycline-overdosed calves, and further suggest myocardial and striated muscular toxicity as well as renal toxicity in doxycycline-overdosed calves.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/92834
also: http://hdl.handle.net/2268/102991
10.1111/j.1939-1676.2010.0560.x

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