Article (Scientific journals)
Extravasation of albumin after cardiopulmonary bypass in newborns.
Tassani, Peter; Schad, Hubert; Schreiber, Christian et al.
2007In Journal of Cardiothoracic and Vascular Anesthesia, 21 (2), p. 174-178
Peer Reviewed verified by ORBi
 

Files


Full Text
Seghaye-2007-extravasation of albumin.pdf
Publisher postprint (172.26 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Analysis of Variance; Blood Pressure; Capillary Leak Syndrome/diagnosis/etiology/metabolism/physiopathology; Capillary Permeability; Cardiac Surgical Procedures; Cardiopulmonary Bypass/adverse effects; Coloring Agents; Evans Blue; Female; Heart Rate; Humans; Infant, Newborn; Inflammation Mediators/metabolism; Injections, Intravenous; Interleukin-10/metabolism; Interleukin-6/metabolism; Male; Osmotic Pressure; Prospective Studies; Serum Albumin/metabolism; Transposition of Great Vessels/metabolism/physiopathology/surgery; Treatment Outcome
Abstract :
[en] OBJECTIVE: The systemic inflammatory response to cardiopulmonary bypass (CPB) possibly increases microvascular permeability to plasma proteins, leading to capillary leak syndrome. The study was conducted to elucidate any protein leakage in newborns using Evans blue dye as tracer. DESIGN: Prospective controlled study. SETTING: University-affiliated heart center. PARTICIPANTS: Eleven neonates with transposition of the great arteries. INTERVENTIONS: Plasma interleukin-6 (IL-6), IL-10, fractional escape rate (FER) of an intravenous bolus of Evans blue, and colloid osmotic pressure (COP) were assessed before and after surgery (statistics: median and 25th-75th percentile, Friedman's 2-way analysis of variance, and Wilcoxon matched-pairs signed-rank test [before and after surgery]). MEASUREMENTS AND MAIN RESULTS: All patients had an uneventful intraoperative course. The demographic and operative data were age 11 (10-13) days, body weight 3.2 (3.0-3.3) kg, CPB time 132 (123-144) minutes, and aortic cross-clamp time 66 (64-78) minutes. The proinflammatory IL-6 increased 60-fold and the anti-inflammatory IL-10 only 3-fold after CPB. FER, however, was not changed, whereas COP was significantly reduced after CPB. CONCLUSIONS: In contrast to the expectation, the escape rate of Evans blue, reflecting the extravasation of albumin, was not increased after CPB. However, reduced COP, hypothermia, and also a reduced lymphatic drainage may contribute to edema formation. The present data do not support the hypothesis of a capillary leak after CPB in newborns.
Disciplines :
Pediatrics
Author, co-author :
Tassani, Peter;  Deutsches Herzzentrum München > Anesthesiology
Schad, Hubert;  Deutsches Herzzentrum München > Cardiovascular Surgery
Schreiber, Christian;  Deutsches Herzzentrum München > Cardiovascular Surgery
Zaccaria, Francesco;  Deutsches Herzzentrum München > Anesthesiology
Haas, Felix;  Wilhelmina Childrens Hospita, Utrecht, The Netherlands > Cardiovascular Surgery
Mossinger, Hansjorg;  Deutsches Herzzentrum München > Anesthesiology
Altmeyer, Sophie;  Deutsches Herzzentrum München > Anesthesiology
Kohler, Raphael;  Deutsches Herzzentrum München > Anesthesiology
SEGHAYE, Marie-Christine ;  Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology
Lange, Rudiger;  Deutsches Herzzentrum München > Cardiovascular Surgery
Language :
English
Title :
Extravasation of albumin after cardiopulmonary bypass in newborns.
Publication date :
April 2007
Journal title :
Journal of Cardiothoracic and Vascular Anesthesia
ISSN :
1053-0770
eISSN :
1532-8422
Publisher :
W.B. Saunders, Philadelphia, United States - Pennsylvania
Volume :
21
Issue :
2
Pages :
174-178
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 June 2011

Statistics


Number of views
67 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
19
Scopus citations®
without self-citations
18
OpenCitations
 
15

Bibliography


Similar publications



Contact ORBi