Article (Scientific journals)
Antioxydant activity of β-carboline derivatives in the LDL oxidation model
Hadjaz, Fariza; Besret, Soizic; Martin-Nizard, Françoise et al.
2001In European Journal of Medicinal Chemistry, 46, p. 2575-2585
Peer Reviewed verified by ORBi
 

Files


Full Text
Hadjaz-EJMC-2011.pdf
Publisher postprint (761.09 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
beta-Carboline; Antioxidant; Inhibition LDL peroxidation; Melatonin
Abstract :
[en] A series of b-carboline compounds were synthesized, starting from compound GWC22, their antioxidant activity was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,20-azobis(2-amidinopropane) dihydrochloride (AAPH). The protective actions of these compounds against the cytotoxicity were evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Most of compounds showed an higher antioxidant activity than GWC22 derivative (R = 1.6 for 5 mM CuSO4). The best antioxidant activities are phenolic and benzyloxy derivatives with ratio R = 1.9 to 2.8 for 1 mM CuSO4. These substances have protective actions and increase significantly the cell viability.
Research center :
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université Lille Nord de France
Département de Pharmacologie Médicale, Faculté de Pharmacie, Université Lille Nord de France
Institut Pasteur de Lille, Faculté de Pharmacie, Université Lille Nord de France
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Hadjaz, Fariza;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Besret, Soizic;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Martin-Nizard, Françoise;  Université Lille Nord de France > Institut Pasteur de Lille, Faculté de Pharmacie
Yous, Said;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Dilly, Sébastien ;  Université de Liège - ULiège > Giga Neurosciences - CIRM > Laboratoire de pharmacologie - Laboratoire de Chimie Pharmaceutique
Lebegue, Nicolas;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Chavatte, Philippe;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Duriez, Patrick;  Université Lille Nord de France > Faculté de Pharmacie > Département de Pharmacologie Médicale
Berthelot, Pascal;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Carato, Pascal;  Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique
Language :
English
Title :
Antioxydant activity of β-carboline derivatives in the LDL oxidation model
Publication date :
June 2001
Journal title :
European Journal of Medicinal Chemistry
ISSN :
0223-5234
eISSN :
1768-3254
Publisher :
Elsevier, Paris, France
Volume :
46
Pages :
2575-2585
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 June 2011

Statistics


Number of views
136 (2 by ULiège)
Number of downloads
3 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi