Reference : Molecular modeling of phthalates – PPARs interactions
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Engineering, computing & technology : Computer science
http://hdl.handle.net/2268/92666
Molecular modeling of phthalates – PPARs interactions
English
Kambia, Nicolas [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Pharmacie Clinique > >]
Renault, Nicolas [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
Dilly, Sébastien [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
Farce, Amaury [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
Dine, Thierry [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Pharmacie Clinique > >]
Gressier, Bernard [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Pharmacie Clinique > >]
Luyckx, Michel [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Pharmacie Clinique > >]
Brunet, Claude [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Pharmacie Clinique > >]
Chavatte, Philippe mailto [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
Oct-2008
Journal of Enzyme Inhibition & Medicinal Chemistry
Taylor & Francis Health Sciences
23
5
611-616
Yes (verified by ORBi)
International
1475-6366
1475-6374
London
United Kingdom
[en] DEHP ; MEHP ; TOTM ; PPARs ; docking
[en] Di(2-ethylhexyl) phthalate (DEHP) is the most widely plasticizer for polyvinyl chloride (PVC) that is used in plastic tubes, in medical and paramedical devices as well as in food storage packaging. The toxicological profile of DEHP has been evaluated in a number of experimental animal models and has been extensively documented. Its toxicity is in part linked to the activation of the peroxisome proliferator-activated receptor a (PPARa). As a response, an intensive research for a new, biologically inert plasticizer has been initiated. Among the alternative studied, tri(2-ethylhexyl) trimellitate (TEHTM) or trioctyl trimellitate (TOTM) has attracted increasing interest. However, very little information is available on their biological effects. We proceeded to dock TOTM, DEHP and its metabolites in order to identify compounds that are likely to interact with PPARa and PPARg binding sites. The results obtained hint that TOTM is not able to bind to PPARs and should therefore be safer than DEHP.
Laboratoire de Pharmacie Clinique, Université de Lille 2 ; Laboratoire de Chimie Thérapeutique, Université de Lille 2
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/92666

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