ORBi: Farce Amaury - Homology modeling of MT(1) and MT(2) receptors

Reference : Homology modeling of MT(1) and MT(2) receptors


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Computer science Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/92665

Title :	Homology modeling of MT(1) and MT(2) receptors
Language :	English
Author, co-author :	Farce, Amaury [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Chugunov, Anton O. [Russian Academy of Sciences of Moscow > Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry > > >]
	Logé, Cédric [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Sabaouni, Ahmed [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Yous, Said [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Dilly, Sébastien [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Renault, Nicolas [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Vergoten, Gérard [Université des Sciences et Technologies de Lille - USTL > UMR CNRS 8576 ‘‘Glycobiologie Structurale et Fonctionnelle’’ > > >]
	Efremov, Roman G. [Russian Academy of Sciences of Moscow > Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry > > >]
	Lesieur, Daniel [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
	Chavatte, Philippe [Université de Lille 2 > Faculté des Sciences Pharmaceutiques et Biologiques > Laboratoire de Chimie Thérapeutique > >]
Publication date :	Sep-2008
Journal title :	European Journal of Medicinal Chemistry
Publisher :	Elsevier
Volume :	43
Pages :	1926-1944
Audience :	International
ISSN :	0223-5234
City :	Paris
Country :	France
Keywords :	[en] Melatonin ; GPCRs ; Activation ; Docking
Abstract :	[en] Melatonin is a neurohormone synthesized and secreted mainly during the dark period of the circadian cycle by the pineal gland. It has already been proved to be involved in a number of chronobiological processes, most of them being mediated by its membranar receptors MT1 and MT2. Both are members of the GPCR class and, despite the interest they elicit, their 3D structure is still to be described. Models for both human MT1 and MT2 receptors have been constructed by homology modeling, using the X-ray structure of bovine rhodopsin as template. These models have been evaluated in terms of hydrophobic properties of the helices and refined to take into account the rearrangement of GPCRs necessary for their activation, thus leading to a putative activated model for each subtype.
Research units :	Laboratoire de Chimie Thérapeutique, Université de Lille 2 ; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/92665
DOI :	10.1016/j.ejmech.2007.12.001

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