|Reference : Establishment of a new Tet-On cell line inducible for expression of CIPAR1 gene|
|Scientific conferences in universities or research centers : Scientific conference in universities or research centers|
|Life sciences : Biochemistry, biophysics & molecular biology|
|Establishment of a new Tet-On cell line inducible for expression of CIPAR1 gene|
|Cornet, Anne [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]|
|EC Gene Therapy Network Meeting|
|Dr J. Closset, service de Biochimie humaine|
|[en] apoptosis ; cipar1 gene ; prostate|
|[en] In prostate cancer therapy, the components of the cell death could play an important role: it is conceivable that targeted tranfer of such genes into prostatic cells could be useful. In our laboratory, a new gene, the CIPAR1 (fro Castration Induced Prostatic Apoptosis Related 1), was identified by Marc Bruyninx. This gene is upregulated when the rat prostate is induced to undergo apoptosis. To learn more about the cellular function of the CIPAR1, we have decided to establish a stable cell line inducible for the expression of CIPAR1 using the "Tet-On expression system" of Clontech. Thanks to this system, we now possess a Tet-On cell line expressing CIPAR1 under Tet control. It has a high expression level of CIPAR1 and this expression can be quantitatively regulated. We hope that this stable cell line will let us elucidate the cellular functions of CIPAR1.|
|Service de Biochimie Humaine, C.H.U., University de Liège|
|EC Gene therapy Network|
|Researchers ; Professionals|
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