Reference : Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma fro...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/91883
Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
English
Gusareva, Elena mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
Bragina, Elena mailto [Research Institute of Medical Genetics, Tomsk, Russia > Population Genetics > > >]
Buinova, Svetlana mailto [Irkutsk State Institute for Post-graduate Medical Education, Irkutsk, Russia > Department of Allergology and Pulmonology > > >]
Chernyak, Boris mailto [Irkutsk State Institute for Post-graduate Medical Education, Irkutsk, Russia > Department of Allergology and Pulmonology > > >]
Puzyrev, Valery mailto [Research Institute of Medical Genetics, Tomsk, Russia > Population genetics > > >]
Ogorodova, Ludmila mailto [Siberian State Medical University, Tomsk, Russia > Medical Genetics > > >]
Lipoldová, Marie mailto [Institute of Molecular Genetics v.v.i., AS CR, Prague, Czech Repub > Dep. of Molecular and Cellular Immunology > > > >]
30-Jun-2009
Immunol Letters
125
1
1-6
Yes (verified by ORBi)
International
0165-2478
Netherlands
[en] asthma, cat allergens, 12q24 ; total and specific IgE ; Siberian population
[en] In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens
(cat, dog and house dust mites), overproduction of total immunoglobulin E (IgE) and airway hyperreactivity.
Definition of genes that predispose to development of various sub-components of the asthma
phenotype is important for understanding of etiology of this disease. To map genes predisposing to
asthma,we tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear
families with asthma from Siberia.We performed non-parametric analysis for linkage with asthma, total
IgE, specific IgE to cat, dog, and dust mites, and spirometric indices (FEV1 (%) – percentage of predicted
forced expiratory volume in 1 s, FVC (%) – percentage of predicted forced vital capacity, and FEV1/FVC (%)
– Tiffenau index). The most significant linkagewas to the candidate region on chromosome 12. Locus controlling
cat-specific IgE, which is the most abundant in asthma patients fromSiberian population, mapped
within the interval between 136 and 140 cM on chromosome 12q24.3, with the suggestive linkage at the
marker D12S1611 (LOD= 2.23, P = 0.0007). Total IgE was also linked to this region (D12S1611 – LOD= 1.12,
P = 0.012). FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus 12q24.3, but with the
peak at a more proximal region at 111.87cM (D12S338 – LOD= 1.21, P = 0.009). Some evidence of linkage
(LOD> 1.0) was also detected for asthma at 6p21.31 (D6S291) and total IgE at 13q14.2 (D13S165). These
data indicate that the locus 12q24.3 is the most promising candidate for identification of asthma genes
in Russian population of Siberia.
Impact of genetic and environmental factors on development of atopy and allergic diseases in human populations
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/91883
10.1016/j.imlet.2009.05.003

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