[en] Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantal follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. In addition, activin preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine follicles, and additional activin stimulates development of those follicles.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hulshof, S. C. J.; University of Utrecht - Netherlands > Dept of Functional Morphology Heard Health and Reproduction
Figueiredo, J. R.; Université de Liège - ULiège - ULG > Dept of animal endocrinology
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Bevers, M. M.; University of Utrecht - Netherlands > Dept of Functional Morphology Herd Health and Reproduction
Vanderstichele, H.; Inogenetics - Ghent Belgium
Language :
English
Title :
Bovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro
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