Reference : The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of p...
Scientific congresses and symposiums : Paper published in a book
Life sciences : Microbiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/91752
The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of penicillin action
English
Ghuysen, Jean-Marie [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie]
Leyh-Bouille, Mélina [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie]
Frère, Jean-Marie mailto [Université de Liège - ULg]
Dusart, Jean [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie]
Perkins, Harold R. [National Institute for Medical Research - London]
Nieto, Manuel [National Institute for Medical Research - London]
1972
Medicinal Chemistry : Special contributions - Milan 1972
Pratesi, P.
Butterworths
1-11
No
International
London
3rd International Symposium on Medicinal Chemistry
1972
Milan
Italy
[en] penicillin
[en] A new model for the transpeptidation reaction involved in the biosynthesis of the bacterial wall peptidoglycan and for its inhibition by penicillin is proposed. This model is in open conflict with the hypotheses previously postulated. It rests upon the demonstration that 1) carboxypeptidase and transpep-tidase activities are performed by the same enzyme, 2) inhibition of both activities by penicillin is carried out in the absence of irreversible acylation of the protein, 3) the enzyme contains multiple sites some of which are involved in regulation, 4) penicillin does not act as a structural analogue of the donor peptide involved in transpeptidation but may act at the level of regulatory site(s).
Centre d'ingénierie des protéines - CIP
Researchers ; Professionals
http://hdl.handle.net/2268/91752

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