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| Reference : On the streptomyces albus G DD Carboxypeptidase mechanism of action on penicillin, vanco... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Microbiology | |||
| http://hdl.handle.net/2268/91733 | |||
| On the streptomyces albus G DD Carboxypeptidase mechanism of action on penicillin, vancomycin and ristocetin | |
| English | |
| Leyh-Bouille, Mélina [Université de Liège - ULg > > Service de Bactériologie > >] | |
| Ghuysen, Jean-Marie [Université de Liège - ULg > > Service de Bactériologie > >] | |
| Nieto, Manuel [National Institut for Medical Research > > > >] | |
| Perkins, Harold R. [National Institut for Medical Research > > > >] | |
| Schleifer, Karl H. [Botanisches Institut der Universität > > > >] | |
| Kandler, Otto [Botanisches Institut der Universität > > > >] | |
| 1970 | |
| Biochemistry | |
| American Chemical Society | |
| 9 | |
| 15 | |
| 2971-2975 | |
| International | |
| 0006-2960 | |
| 1520-4995 | |
| Washington | |
| DC | |
| [en] The activity of the D-alanyl-D carboxypeptidase from the penicillin-resistant Streptomyces albus G is not or very little affected by penicillins and related antibiotics. The molecular basis for the mechanism of action of penicillin is discussed. The Streptomyces albus G D-alanyl-D carboxypeptidase appears as a model for the study of a mechanism of penicillin resistance that does not involve the enzymatic degradation of the antibiotic. Vancomycin and ristocetin are shown to inhibit the hydrolysis of sensitive peptides by the Streptomyces albus G D-alanyl-D carboxypeptidase and the mechanism of inhibition is discussed. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/91733 | |
| 10.1021/bi00817a006 |
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