Reference : Design of reversibly core cross-linked micelles sensitive to reductive environment
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/91529
Design of reversibly core cross-linked micelles sensitive to reductive environment
English
Cajot, Sébastien mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Lautram, N. [University of Angers (France) > > INSERM > >]
Passirani, Catherine [University of Angers (France) > > INSERM > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
30-May-2011
Journal of Controlled Release
Elsevier Science
152
1
30-36
Yes (verified by ORBi)
International
0168-3659
1873-4995
Amsterdam
The Netherlands
[en] self-assembly in solution ; copper-mediated Huisgen's cycloaddition ; micelle ; click chemistry ; stimuli responsive micelle
[en] Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in order to build micellar drug delivery systems. Such azido groups being able to react by alkyne-azide 1,3 Huisgens cycloaddition (a click reaction) have been used further in order to cross-link the micelles via redox-sensitive disulfide bridges. This reversible cross-linking allows to prevent micelles dissociation at high dilution upon injection and to trigger their dissociation in more reductive environment, such as the cytosol. Copolymers having three different architectures, i.e. able to crosslink either the core or the shell of core-shell-corona system have been used to investigate their micellization, cross-linking and cross-linking reversibility. The stealthiness of these micelles crosslinked in the hydrophobic segment has also been studied in vitro.
Center for Education and Research on Macromolecules (CERM)
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/91529
10.1016/j.jconrel.2011.03.026
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3D-52H3RNH-7-1&_cdi=4944&_user=532038&_pii=S0168365911001623&_origin=search&_coverDate=03%2F30%2F2011&_sk=999999999&view=c&wchp=dGLbVlb-zSkWA&md5=ba9c24cec562117c95c7f6cc5bb0cbd8&ie=/sdarticle.pdf
The authors acknowledge Journal of Controlled Release (Elsevier) for allowing them to archive this paper.

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