Article (Scientific journals)
Membrane-type matrix metalloproteinase-1 expression at the site of human placentation
Nawrocki, B.; Polette, M. E.; Marchand, V. et al.
1996In Placenta, 17 (8), p. 565-72
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Abstract :
[en] Human trophoblast implantation is a highly regulated process of invasion that requires action of proteolytic enzymes to degrade extracellular matrix components of the endometrium. Among these enzymes, matrix metalloproteinases (MMPs) seem to be particularly important in this degradative process. We previously showed that gelatinase A is extensively expressed in vivo in the human placenta. A new MMP, MT-MMP-1 (membrane-type matrix metalloproteinase-1), which is thought to activate progelatinase A, has recently been described. In this study, we examined the expression of MT-MMP-1, by immunohistochemistry and in situ hybridization, in human placental bed biopsies taken during the first trimester of gestation. Human first trimester intermediate trophoblasts synthesized MT-MMP-1 mRNAs and the protein. The MT-MMP-1 pattern of distribution in placental beds was similar to that of gelatinase A, suggesting a pivotal role for MT-MMP-1 in placentation, perhaps by activating progelatinase A.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Nawrocki, B.
Polette, M. E.
Marchand, V.
Maquoi, Erik  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Beorchia, A.
Tournier, J. M.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Birembaut, P.
Language :
English
Title :
Membrane-type matrix metalloproteinase-1 expression at the site of human placentation
Publication date :
1996
Journal title :
Placenta
ISSN :
0143-4004
eISSN :
1532-3102
Publisher :
W.B. Saunders, London, United Kingdom
Volume :
17
Issue :
8
Pages :
565-72
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 May 2011

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