Androstatrienes/pharmacology; Animals; Animals, Newborn/physiology; Ejaculation/physiology; Estrus/physiology; Female; Male; Rats; Rats, Wistar; Sexual Behavior, Animal/physiology; Social Isolation
Abstract :
[en] Male rats were neonatally treated with cholesterol or a substance that blocks the aromatization of testosterone to estradiol (1,4,6-androstatriene-3,17-dione: ATD). At weaning (21 days) they were either housed alone or in small groups (2-3 animals) and tested for partner preference behavior (PPB) in adulthood. Choice was between an estrous female and an active male (Part I) and between an estrous female and an ATD-male (Part II). Tests were carried out in a 3-compartment box. Social isolation did not have major effects on PPB except when sexual interaction with the stimulus animals was prevented (Part I). In this case, isolates (ATD and control) showed higher preference scores (PS) for the estrous female and spent less time in the empty middle compartment. When the choice was between an estrous female and an ATD-male, partner PS decreased in all males, most clearly in ATD-males. The latter animals spent more time with the stimulus ATD-male than they had done in previous PPB tests with the normal stimulus male. In contrast to partner preference behaviors, sexual behavior was clearly affected by social isolation. Isolates (ATD and control) displayed lower frequencies of mounts and intromissions. These effects persisted over consecutive tests. Ejaculation was not affected. In conclusion, the present results confirm earlier findings about the significance of neonatal endocrine conditions for the organization of adult PPB in male rats. The presence or absence of social conspecifics after weaning appears to have little influence on adult PPB.
Research center :
Erasmus University Rotterdam
Disciplines :
Neurosciences & behavior
Author, co-author :
Bakker, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
van Ophemert, J.
Slob, A. K.
Language :
English
Title :
Postweaning housing conditions and partner preference and sexual behavior of neonatally ATD-treated male rats.
Publication date :
1995
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Pergamon Press (part of Elsevier Science), Oxford, United Kingdom
Adkins-Regan (1988) Sex hormones and sexual orientation in animals. Psychobiology 16:335-347.
Bakker, Brand, van Ophemert, Slob (1993) Hormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats. Behav Neurosci 107:480-487.
Bakker, van Ophemert, Slob (1993) Organization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats. Behav Neurosci 107:1049-1058.
Baum (1979) Differentiation of coital behavior in mammals: A comparative analysis. Neurosci Biobehav Rev 3:265-284.
Baum, Tobet (1986) Effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. Physiol Behav 37:111-118.
Beach (1942) A comparison of copulatory behavior of male rats raised in isolation, cohabitation and segregation. J Gen Psychol 60:121-136.
Beach (1958) Normal sexual behavior in male rats isolated at fourteen days of age. J Comp Physiol Psychol 51:37-38.
Brand, Kroonen, Mos, Slob (1991) Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations. Horm Behav 25:323-341.
Brodie, Marsh, Wu, Brodie (1979) Aromatase inhibitors and their use in controlling oestrogen-dependent processes. J Steroid Biochem 11:107-112.
Davis, Chaptal, McEwen (1979) Independence of the differentiation of masculine and feminine sexual behavior in rats. Horm Behav 12:12-19.
Edwards, Pfeifle (1983) Hormonal control of receptivity, proceptivity and sexual motivation. Physiol Behav 30:437-443.
Gerall, Ward, Gerall (1967) Disruption of the male rat's sexual behavior induced by social isolation. Anim Behav 15:54-58.
Gruendel, Arnold (1969) Effects of early social deprivation on reproductive behavior of male rats. J Comp Physiol Psychol 67:123-128.
Hård, Larsson (1968) Dependence of adult mating behavior in male rats on the presence of littermates in infancy. Brain, Behavior and Evolution 1:405-419.
Kagan, Beach (1953) Effects of early experience on mating behavior in male rats. J Comp Physiol Psychol 46:204-208.
Kaplan, McGinnis (1989) Effects of ATD on male sexual behavior and androgen receptor binding: A reexamination of the aromatization hypothesis. Horm Behav 23:10-26.
Kirk Experimental Design: Procedures for the Behavioral Sciences, Brooks/Cole, Belmont, California; 1968.
Larsson (1956) Conditioning and Sexual Behavior in the Male Albino Rat. Acta Psychologia Gothoburgensia , Almqvist & Wiksell, Stockholm; 1.
Lieberburg, Wallach, McEwen (1977) The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (CI 628) on in vivo formed testosterone metabolites recovered from neonatal brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain. Brain Res 128:176-181.
Slob, de Klerk, Brand (1987) Homosexual and heterosexual partner preference in ovariectomized female rats: Effects of testosterone, estradiol and mating experience. Physiol Behav 41:571-576.
Spevak, Quadagno, Knoeppel, Poggio (1973) The effects of isolation on sexual and social behavior in the rat. Behav Biol 8:63-73.
Tobet, Baum (1987) Role of prenatal estrogen in the development of masculine sexual behavior in the male ferret. Horm Behav 21:419-429.
Vega Matuszczyk (1993) The differentiation of sexual behavior and partner preference of the male rat. PhD thesis, Göteborgs Universiteit, Sweden; .
Vreeburg, van der Vaart, van der Schoot (1977) Prevention of central defeminization but not masculinization in male rats by inhibition neonatally of estrogen biosynthesis. J Endocrinol 74:375-382.
Ward, Reed (1985) Prenatal stress and prepuberal social rearing conditions interact to determine sexual behavior in male rats. Behavioral Neuroscience 2:301-309.
Zimbardo (1958) The effects of early avoidance training and rearing conditions upon the sexual behavior of the male rat. J Comp Physiol Psychol 51:764-769.