Reference : Role for Estradiol in Female-Typical Brain and Behavioral Sexual Differentiation
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/91356
Role for Estradiol in Female-Typical Brain and Behavioral Sexual Differentiation
English
Bakker, Julie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Baum, M. J. [> > > >]
Jan-2008
Frontiers in Neuroendocrinology
29
1
1-16
Yes (verified by ORBi)
International
0091-3022
1095-6808
[en] hormones ; brain ; behavior
[en] The importance of estrogens in controlling brain and behavioral sexual differentiation in female rodents is an unresolved issue in the field of behavioral neuroendocrinology. Whereas, the current dogma states that the female brain develops independently of estradiol, many studies have hinted at possible roles of estrogen in female sexual differentiation. Accordingly, it has been proposed that alpha-fetoprotein, a fetal plasma protein that binds estrogens with high affinity, has more than a neuroprotective role and specifically delivers estrogens to target brain cells to ensure female differentiation. Here, we review new results obtained in aromatase and alpha-fetoprotein knockout mice showing that estrogens can have both feminizing and defeminizing effects on the developing neural mechanisms that control sexual behavior. We propose that the defeminizing action of estradiol normally occurs prenatally in males and is avoided in fetal females because of the protective actions of alpha-fetoprotein, whereas the feminizing action of estradiol normally occurs postnatally in genetic females.
Giga-Neurosciences
NICHD
Researchers ; Students
http://hdl.handle.net/2268/91356
10.1016/j.yfrne.2007.06.001

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