Reference : Development and in vitro characterisation of novel bioresorbable and bioactive compos...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/9134
Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
English
Roether, J. A. [Imperial College, London, UK > > Centre for Composite Materials > >]
Boccaccini, Aldo R. [Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering > > >]
Hench, L. L. [Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering > > >]
Maquet, Véronique [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Gautier, Sandrine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Sep-2002
Biomaterials
Elsevier
23
18
3871-3878
Yes (verified by ORBi)
International
0142-9612
Oxford
[en] biomaterial ; scaffold ; foam
[en] Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering.
Center for Education and Research on Macromolecules (CERM)
The Nuffield Foundation, London (Grant No. NAL/00196/G) ; The EPSRC ; The UK Medical Research Council ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/9134
10.1016/S0142-9612(02)00131-X
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TWB-45XTP7K-2-N&_cdi=5558&_user=532038&_orig=browse&_coverDate=09%2F30%2F2002&_sk=999769981&view=c&wchp=dGLbVzb-zSkzV&md5=20dd739b8839fa7f89b4fd2204274969&ie=/sdarticle.pdf
http://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#description
The authors acknowledge Biomaterials (Elsevier) for allowing them to archive this paper.

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