Article (Scientific journals)
Bioresorbable and bioactive composite materials based on polylactide foams filled with and coated by Bioglass (R) particles for tissue engineering applications
Boccaccini, Aldo R.; Notingher, I.; Maquet, Véronique et al.
2003In Journal of Materials Science: Materials in Medicine, 14 (5), p. 443-450
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Keywords :
biomaterial; scaffold; foam
Abstract :
[en] Poly(DL-lactide) (PDLLA) foams and bioactive glass (Bioglass®) particles were used to form bioresorbable and bioactive composite scaffolds for applications in bone tissue engineering. A thermally induced phase separation process was applied to prepare highly porous PDLLA foams filled with 10wt% Bioglass® particles. Stable and homogeneous layers of Bioglass® particles on the surface of the PDLLA/Bioglass® composite foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of the PDLLA/Bioglass® composites, as an indication of the bioactivity of the materials. Formation of the HA layer after immersion in SBF was confirmed by X-ray diffraction and Raman spectroscopy measurements. The rate of HA formation in Bioglass®-coated samples was higher than that observed in non-coated samples. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF in the Bioglass®-coated samples. The high bioactivity of the developed composites suggests that the materials are attractive for use as bioactive, resorbable scaffolds in bone tissue engineering.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Boccaccini, Aldo R.;  Imperial College, London, UK > Department of Materials and Tissue Engineering
Notingher, I.;  Imperial College, London, UK > Department of Materials and Tissue Engineering
Maquet, Véronique;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Bioresorbable and bioactive composite materials based on polylactide foams filled with and coated by Bioglass (R) particles for tissue engineering applications
Publication date :
May 2003
Journal title :
Journal of Materials Science: Materials in Medicine
ISSN :
0957-4530
eISSN :
1573-4838
Publisher :
Kluwer Academic Publ, Dordrecht, Netherlands
Volume :
14
Issue :
5
Pages :
443-450
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The Nuffield Foundation, London
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
The original publication is available at www.springerlink.com/content/tu5741x350637337/?p=eb83e39ea09049b5943f946976ecbe95π=1. The authors acknowledge Journal of Materials Science: Materials in Medicine (Springer) for allowing them to archive this paper.
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