Reference : N-acetylcysteine lacks universal inhibitory activity against influenza A viruses.
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/2268/90865
N-acetylcysteine lacks universal inhibitory activity against influenza A viruses.
English
Garigliany, Mutien-Marie mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies]
Desmecht, Daniel mailto [ > > ]
2011
Journal of negative results in biomedicine
10
1
5
Yes (verified by ORBi)
International
1477-5751
1477-5751
[en] ABSTRACT: N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication in vitro and to attenuate the severity of the disease in mouse models. Although available studies were made with different viruses (human and avian), published information related to the anti-influenza spectrum of NAC is scarce. In this study, we show that NAC is unable to alter the course of a fatal influenza pneumonia caused by inoculation of a murinized swine H1N1 influenza virus. NAC was indeed able to inhibit the swine virus in vitro but far less than reported for other strains. Therefore, susceptibility of influenza viruses to NAC appears to be strain-dependent, suggesting that it cannot be considered as a universal treatment for influenza pneumonia.
http://hdl.handle.net/2268/90865
10.1186/1477-5751-10-5

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