Reference : Brain function in the vegetative state
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/908
Brain function in the vegetative state
English
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Antoine, S. [> > > >]
Boly, Mélanie mailto [Université de Liège - ULg > > Neurologie >]
Elincx, S. [> > > >]
Faymonville, Marie-Elisabeth mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Berré, Jacques [> > > >]
Sadzot, Bernard [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
Ferring, Martine [> > > >]
De Tiège, Xavier [> > > >]
van Bogaert, Patrick [> > > >]
Hansen, Isabelle [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Damas, Pierre mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Mavroudakis, Nicolas [> > > >]
Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Del Fiore, Guy [> > > >]
Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Phillips, Christophe [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Franck, Georges [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Vincent, Jean-Louis [> > > >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Goldman, Serge [> > > >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Dec-2002
Acta Neurologica Belgica
Acta Medica Belgica
102
4
177-185
Yes (verified by ORBi)
National
0300-9009
Brussels
Belgique
[en] vegetative state ; consciousness ; functional neuroimaging ; positron emission tomography ; brain metabolism, cerebral blood flow ; functional connectivity ; brain plasticity
[en] Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e., change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction.
http://hdl.handle.net/2268/908

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