ORBi: Georges Michel - Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation

Reference : Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Life sciences : Genetics & genetic processes Engineering, computing & technology : Computer science
	To cite this reference:	http://hdl.handle.net/2268/90681

Title :	Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation
Language :	English
Author, co-author :	Georges, Michel [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
	Clop, Alex [Université de Liège - ULG > Département de productions animales > GIGA-R : Génomique animale > >]
	Marcq, Fabienne [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
	Takeda, Haruko [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
	Pirottin, Dimitri [Université de Liège - ULg > Département de sciences fonctionnelles > Département de sciences fonctionnelles >]
	Tordoir, Xavier [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
	Hiard, Samuel [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation > > >]
	Bibé, B. [Institut National de la Recherche Agronomique > Station d'Amélioration Génétique des Animaux > > >]
	Bouix, J. [Institut National de la Recherche Agronomique > Station d'Amélioration Génétique des Animaux > > > >]
	Caiment, Florian [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
	Eychenne, F. [Institut National de la Recherche Agronomique > Station d'Amélioration Génétique des Animaux > > > >]
	Larzul, C. [Institut National de la Recherche Agronomique > Station d'Amélioration Génétique des Animaux > > > >]
	Laville, E. [Institut National de la Recherche Agronomique > Station d'Amélioration Génétique des Animaux > > > >]
	Meish, F. [Université de Liège - ULG > Département de productions animales > GIGA-R : Génomique animale > >]
	Milenkovic, D. [Institut Scientifique de Recherche Agronomique - INRA > Faculté des sciences > > >]
	Tobin, J. [University of Cambridge > Wyeth Research > Cardiovascular and Metabolic Diseases > >]
	Charlier, Carole [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Publication date :	Jun-2006
Journal title :	Cold Spring Harbor Symposia on Quantitative Biology
Publisher :	Cold Spring Harbor Laboratory Press
Volume :	71
Pages :	343-350
Peer reviewed :	Yes (verified by ORBi)
On invitation :	No
Audience :	International
ISSN :	0091-7451
City :	Woodbury
Country :	NY
Event name :	Cold Spring Harbor Symposia on Quantitative Biology 2006
Event date :	2006
Event organizer :	Bruce Stillman and David Stewart
Event place (city) :	New York
Event country :	USA
Keywords :	[en] bioinformatics ; Polymorphic ; miRNA ; target ; interaction ; phenotypic
Abstract :	[en] Studying the muscular hypertrophy of Texel sheep by forward genetics, we have identified an A-to-G transition in the 3'UTRof the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. This causes the down-regulation of this muscle-specific chalone and hence contributes to the muscular hypertrophyof Texel sheep. We demonstrate that polymorphisms which alter the content of putative miRNA target sites are commonin human and mice, and provide evidence that both conserved and nonconserved target sites are selectively constrained. Wespeculate that these polymorphisms might be important mediators of phenotypic variation including disease. To facilitatestudies along those lines, we have constructed a database (www.patrocles.org) listing putative polymorphic microRNA–targetinteractions.
Research units :	Systmod
Target :	Professionals
Permalink :	http://hdl.handle.net/2268/90681
DOI :	10.1101/sqb.2006.71.056
Other URL :	http://www.montefiore.ulg.ac.be/services/stochastic/pubs/2006/GCMTPTHBBCELLMMTC06
Commentary :	Regulatory RNAs - Cold Spring Harbor Symposium on Quantitative Biology

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