Article (Scientific journals)
Brain functional integration decreases during propofol-induced loss of consciousness.
Schrouff, Jessica; Perlbarg, Vincent; Boly, Mélanie et al.
2011In NeuroImage, 57 (1), p. 198-205
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Keywords :
Anesthesia; Anesthetics, Intravenous/pharmacology; Brain/drug effects; Consciousness/drug effects/physiology; Image Interpretation, Computer-Assisted; Integration; Magnetic Resonance Imaging; Networks; Neural Pathways/drug effects; Propofol/pharmacology; Young Adult; Unconsciousness/chemically induced
Abstract :
[en] Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Laboratoire d'Imagerie Fonctionnelle, INSERM, UPMC-Paris 6
Disciplines :
Human health sciences: Multidisciplinary, general & others
Neurology
Anesthesia & intensive care
Author, co-author :
Schrouff, Jessica ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Perlbarg, Vincent
Boly, Mélanie ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Marrelec, Guillaume
BOVEROUX, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bruno, Marie-Aurélie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Pélégrini-Issac, Mélanie
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Benali, Habib
Language :
English
Title :
Brain functional integration decreases during propofol-induced loss of consciousness.
Publication date :
2011
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier Science, Orlando, United States - Florida
Volume :
57
Issue :
1
Pages :
198-205
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
European Commission (Mindbridge, DISCOS, CATIA and DECODER)
FMRE - Fondation Médicale Reine Elisabeth [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
French Speaking Community Concerted Research Action (ARC 06/11-340)
JSMF - James S McDonnell Foundation [US-MO]
MSF - Mind Science Foundation [US-TX]
PAI/IAP Interuniversity Pole of Attraction
Research Fund of ULg
Commentary :
Copyright (c) 2011 Elsevier Inc. All rights reserved.
Available on ORBi :
since 09 May 2011

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