ORBi: Schrouff Jessica - Brain functional integration decreases during propofol-induced loss of consciousness.

Reference : Brain functional integration decreases during propofol-induced loss of consciousness.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Anesthesia & intensive care Human health sciences : Neurology Human health sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/137551

Title :	Brain functional integration decreases during propofol-induced loss of consciousness.
Language :	English
Author, co-author :	Schrouff, Jessica [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Perlbarg, Vincent [> > > >]
	Boly, Mélanie [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
	Marrelec, Guillaume [> > > >]
	BOVEROUX, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation]
	Vanhaudenhuyse, Audrey [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Bruno, Marie-Aurélie [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Laureys, Steven [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Phillips, Christophe [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Pélégrini-Issac, Mélanie [> >]
	Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Benali, Habib [> >]
Publication date :	2011
Journal title :	NeuroImage
Publisher :	Elsevier Science
Volume :	57
Issue/season :	1
Pages :	198-205
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1053-8119
e-ISSN :	1095-9572
City :	Orlando
Country :	FL
Keywords :	[en] Anesthesia ; Anesthetics, Intravenous/pharmacology ; Brain/drug effects ; Consciousness/drug effects/physiology ; Image Interpretation, Computer-Assisted ; Integration ; Magnetic Resonance Imaging ; Networks ; Neural Pathways/drug effects ; Propofol/pharmacology ; Young Adult ; Unconsciousness/chemically induced
Abstract :	[en] Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness.
Research units :	Centre de Recherches du Cyclotron - CRC ; Laboratoire d'Imagerie Fonctionnelle, INSERM, UPMC-Paris 6
Funders :	European Commission (Mindbridge, DISCOS, CATIA and DECODER) ; Fondation Médicale Reine Elisabeth ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; French Speaking Community Concerted Research Action (ARC 06/11-340) ; James McDonnell Foundation ; Mind Science Foundation ; PAI/IAP Interuniversity Pole of Attraction ; Research Fund of ULg
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/137551
	also: http://hdl.handle.net/2268/90460
DOI :	10.1016/j.neuroimage.2011.04.020
Commentary :	Copyright (c) 2011 Elsevier Inc. All rights reserved.

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