Reference : Lymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-t...
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/9033
Lymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy.
English
Pierard, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Goffin, Véronique [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Arrese Estrada, Jorge [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Martalo, Oriane [Centre Hospitalier Universitaire de Liège - CHU > > > > Dermatopathologie > >]
Braham, Catherine [Centre Hospitalier Universitaire de Liège - CHU > > > > Dermatopathologie > >]
Slachmuylders, Patricia [> > > >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2002
Skin Pharmacology & Applied Skin Physiology
S. Karger
15
2
112-9
Yes (verified by ORBi)
1422-2868
1422-2906
Basel
Switzerland
[en] Acne Vulgaris/drug therapy/microbiology ; Adolescent ; Adult ; Anti-Bacterial Agents/adverse effects/pharmacology/therapeutic use ; Chi-Square Distribution ; Double-Blind Method ; Female ; Flow Cytometry ; Humans ; Lymecycline/adverse effects/pharmacology/therapeutic use ; Male ; Microbial Sensitivity Tests/methods ; Minocycline/adverse effects/pharmacology/therapeutic use ; Propionibacterium acnes/drug effects/growth & development
[en] BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. METHOD: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. RESULTS: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. CONCLUSION: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg.
http://hdl.handle.net/2268/9033
Copyright 2002 S. Karger AG, Basel

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