Reference : Effects of age and allergen-induced airway inflammation in cats: Radiographic and cytolo...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/9019
Effects of age and allergen-induced airway inflammation in cats: Radiographic and cytologic correlation
English
Kirschvink, Nathalie [> > > >]
Kersnak, Emilie [> > > >]
Leemans, Jérôme mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
Delvaux, François [> >]
Clercx, Cécile mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux >]
Snaps, Frédéric [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Imagerie médicale >]
Gustin, Pascal mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
2007
Veterinary Journal
Elsevier Sci Ltd
174
3
644-651
Yes (verified by ORBi)
International
1090-0233
Oxford
[en] cat ; thorax ; radiography ; asthma ; age ; allergen exposure
[en] Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2) to test if experimentally-induced bronchial inflammation by inhaling Ascaris suum (AS) allergens leads to radiographic changes after single or repeated exposures. Healthy cats (n = 15-30) aged between 6 and 30 months were evaluated. Eight healthy cats and eight AS-sensitised cats, respectively, inhaled sterile saline or allergen. Radiographs were taken 24 h before, and 6, 24 and 48 h after the challenge. Bronchoalveolar lavage (BAL) was performed after the last radiographic examination. AS-sensitised cats underwent three further allergen challenges at 3-month intervals. The radiographic evaluation was based on a scoring system considering bronchial, interstitial and alveolar patterns. A significant age-related increase in interstitial and total radiographic score was detected in healthy cats older than 18 months and in healthy cats older than 24 months. Whilst saline inhalation did not affect radiographic scores, a single AS challenge induced significant changes of all scores within 6-24 h. A significant positive correlation between radiographic scores and BAL neutrophils and eosinophils was found. Repeated AS challenges did not induce irreversible changes in radiographic scores. (c) 2006 Elsevier Ltd. All rights reserved.
Researchers ; Professionals
http://hdl.handle.net/2268/9019
10.1016/j.tvjl.2006.11.010

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