Reference : Novel HDAC/DNMT twin inhibitors interfere with angiogenesis
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/89992
Novel HDAC/DNMT twin inhibitors interfere with angiogenesis
English
Shiva Shankar, Thammadihalli Veerasangaiah mailto [Université de Liège - ULg > > > GIGA - Membres]
Sulka, Béatrice mailto [> >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Noël, Agnes mailto [> >]
Bellahcene, Akeila mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
Castronovo, Vincent mailto [> >]
Lambert, Didier mailto [> >]
Wouters, Johan mailto [> >]
Willems, Luc mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
2010
Yes
Keystone Symposia on Molecular and Cellular Biology
28/02/2010 to 05/03/2010
[en] anti-angiogenic ; HDAC ; DNMT
[en] DNA methylation and histone deacetylation are two key epigenetic modifications that play central role in regulation of gene expression. Several studies have shown that histone deacetylases (HDAC) and DNA methyltransferases (DNMT) inhibitors are potent antiangiogenic compounds. Though combination of HDAC and DNMT inhibitors are now being examined in clinical trials of hematological malignancies, very little work has been done to understand the effect of this combination on normal and tumoral angiogenesis. We have designed and tested a family of twin drugs with intrinsic HDAC and DNMT inhibitory activities in relevant models of angiogenesis in vitro (endothelial cells, pericytes and the 3D aortic ring assay) and in vivo (the chick chorioallantoic membrane assay). We have identified a lead compound having quantifiable antiangiogenic effect without cytotoxicity associated with increased global acetylation and decreased DNA methylation levels. This compound is presently used to develop effective approaches to treat cancer by modulating the process of angiogenesis.
http://hdl.handle.net/2268/89992

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