ORBi: Lambermont Bernard - Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility

Reference : Comparison between single-beat and multiple-beat methods for estimation of right ventric...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Anesthesia & intensive care Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/89876

Title :	Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility
Language :	English
Author, co-author :	Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > Médecine > Soins intensifs médicaux > >]
	Segers, Patrick [> >]
	Ghuysen [Centre Hospitalier Universitaire de Liège - CHU > département de médecine > service des urgences > >]
	Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	Morimont, Philippe [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
	Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
	Kolh, Philippe [Université de Liège - ULg > Département des Sciences Biomédicales et Précliniques > Service de Biochimie et de Physiologie générales, humaines, normales et pathologiques > >]
	Gérard, Paul [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]
	D'Orio, Vincenzo [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Publication date :	Sep-2004
Journal title :	Critical Care Medicine
Publisher :	Lippincott Williams & Wilkins
Volume :	32
Issue/season :	9
Pages :	1886-1890
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0090-3493
City :	Philadelphia
Keywords :	[en] conductance catheter ; contractile function ; hemodynamics ; inotropic agents ; right ventricular function
Abstract :	[en] OBJECTIVE: It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction. DESIGN: Prospective animal research. SETTING: Laboratory at a large university medical center. SUBJECTS: Eight anesthetized pigs. INTERVENTIONS: End-systolic elastance values obtained by a recently proposed single-beat method (Eessb) were compared with those obtained using the reference multiple-beat method (Eesmb). MEASUREMENTS AND MAIN RESULTS: Administration of dobutamine increased Eesmb from 1.6 +/- 0.3 to 3.8 +/- 0.5 mm Hg/mL (p =.001), whereas there was only a trend toward an increase in Eessb from 1.5 +/- 0.2 to 1.7 +/- 0.4 mm Hg/mL. Esmolol decreased Eesmb from 1.7 +/- 0.3 to 1.1 +/- 0.2 mm Hg/mL (p =.006), whereas there was only a trend for a decrease in Eessb from 1.5 +/- 0.2 to 1.3 +/- 0.1. CONCLUSIONS: The present method using single-beat estimation to assess right ventricular contractility does not work as expected, since it failed to detect either increases or decreases in right ventricular contractility induced by pharmacologic interventions.
Permalink :	http://hdl.handle.net/2268/89876
Other URL :	http://www.ccmjournal.com/

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