Reference : Migraine preventive drugs differentially affect cortical spreading depression in rat.
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/89831
Migraine preventive drugs differentially affect cortical spreading depression in rat.
English
Bogdanov, Vladimir mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Multon, Sylvie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine]
Chauvel, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques]
Bogdanova, Olena Viktorivna [> > > >]
Prodanov, Dimiter [> > > >]
Makarchuk, Mykola Yukhymovych [> > > >]
Schoenen, Jean mailto [ > > ]
2011
Neurobiology of Disease
Academic Press
41
2
430-5
Yes (verified by ORBi)
International
0969-9961
1095-953X
San Diego
CA
[en] Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine. To test the hypothesis that their common denominator might be suppression of CSD we studied in rats the effect of three drugs used in migraine prevention: lamotrigine which is selectively effective on the aura but not on the headache, valproate and riboflavin which have a non-selective effect. Rats received for 4 weeks daily intraperitoneal injections of one of the three drugs. For valproate and riboflavin we used saline as control, for lamotrigine its vehicle dimethyl sulfoxide. After treatment, cortical spreading depressions were elicited for 2h by occipital KCl application. We measured CSD frequency, its propagation between a posterior (parieto-occipital) and an anterior (frontal) electrode, and number of Fos-immunoreactive nuclei in frontal cortex. Lamotrigine suppressed CSDs by 37% and 60% at posterior and anterior electrodes. Valproate had no effect on posterior CSDs, but reduced anterior ones by 32% and slowed propagation velocity. Riboflavin had no significant effect at neither recording site. Frontal Fos expression was decreased after lamotrigine and valproate, but not after riboflavin. Serum levels of administered drugs were within the range of those usually effective in patients. Our study shows that preventive anti-migraine drugs have differential effects on CSD. Lamotrigine has a marked suppressive effect which correlates with its rather selective action on the migraine aura. Valproate and riboflavin have no effect on the triggering of CSD, although they are effective in migraine without aura. Taken together, these results are compatible with a causal role of CSD in migraine with aura, but not in migraine without aura.
http://hdl.handle.net/2268/89831
10.1016/j.nbd.2010.10.014
Copyright A(c) 2010 Elsevier Inc. All rights reserved.

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