Article (Scientific journals)
Migraine preventive drugs differentially affect cortical spreading depression in rat.
Bogdanov, Vladimir; Multon, Sylvie; Chauvel, Virginie et al.
2011In Neurobiology of Disease, 41 (2), p. 430-5
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Abstract :
[en] Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine. To test the hypothesis that their common denominator might be suppression of CSD we studied in rats the effect of three drugs used in migraine prevention: lamotrigine which is selectively effective on the aura but not on the headache, valproate and riboflavin which have a non-selective effect. Rats received for 4 weeks daily intraperitoneal injections of one of the three drugs. For valproate and riboflavin we used saline as control, for lamotrigine its vehicle dimethyl sulfoxide. After treatment, cortical spreading depressions were elicited for 2h by occipital KCl application. We measured CSD frequency, its propagation between a posterior (parieto-occipital) and an anterior (frontal) electrode, and number of Fos-immunoreactive nuclei in frontal cortex. Lamotrigine suppressed CSDs by 37% and 60% at posterior and anterior electrodes. Valproate had no effect on posterior CSDs, but reduced anterior ones by 32% and slowed propagation velocity. Riboflavin had no significant effect at neither recording site. Frontal Fos expression was decreased after lamotrigine and valproate, but not after riboflavin. Serum levels of administered drugs were within the range of those usually effective in patients. Our study shows that preventive anti-migraine drugs have differential effects on CSD. Lamotrigine has a marked suppressive effect which correlates with its rather selective action on the migraine aura. Valproate and riboflavin have no effect on the triggering of CSD, although they are effective in migraine without aura. Taken together, these results are compatible with a causal role of CSD in migraine with aura, but not in migraine without aura.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Bogdanov, Vladimir ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Multon, Sylvie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Chauvel, Virginie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Bogdanova, Olena Viktorivna
Prodanov, Dimiter
Makarchuk, Mykola Yukhymovych
Schoenen, Jean  
Language :
English
Title :
Migraine preventive drugs differentially affect cortical spreading depression in rat.
Publication date :
2011
Journal title :
Neurobiology of Disease
ISSN :
0969-9961
eISSN :
1095-953X
Publisher :
Academic Press, San Diego, United States - California
Volume :
41
Issue :
2
Pages :
430-5
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright A(c) 2010 Elsevier Inc. All rights reserved.
Available on ORBi :
since 29 April 2011

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