Reference : Influence of Brain-Derived Neurotrophic Factor val66met human polymorphism on declara...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Neurology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/89716
Influence of Brain-Derived Neurotrophic Factor val66met human polymorphism on declarative memory consolidation during sleep
English
Mascetti, Laura mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Foret, Ariane [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Matarazzo, Luca mailto [Université de Liège - ULg > > Centre de recherches du cyclotron > >]
Muto, Vincenzo mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
DIDEBERG, Vinciane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Bours, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
15-Sep-2010
Journal of Sleep Research
Blackwell Publishing
19
s2
Yes (verified by ORBi)
No
International
0962-1105
1365-2869
Oxford
United Kingdom
20th Congress of the European Sleep Research Society
14 - 18 septembre 2010
European Sleep Research Society
Lisbonne
Portugal
[en] The Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which in the adult brain, regulates long-term potentiation and has been involved in the build up of the homeostatic sleep pressure in rodents. In humans, valine (val) to methionine (met) substitution in the 5’ pro-region of the BDNF protein is associated with poorer episodic memory. Neurons transfected with met-BDNF-Green Fluorescence Protein showed lower depolarization-induced secretion, while constitutive secretion is unchanged. Here, we hypothesized that the differences in BDNF release determined by this polymorphism would influence sleep-dependent memory consolidation and that in comparison with the met-carriers (val/met or met/met), val/val individuals would show higher memory performance after one night of sleep rather than an immediate retrieval session.

This study was supported by FNRS-FRIA, the University of Liège, and the QEMF.
http://hdl.handle.net/2268/89716

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