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Influence of Brain-Derived Neurotrophic Factor val66met human polymorphism on declarative memory consolidation during sleep
Mascetti, Laura; Foret, Ariane; Matarazzo, Luca et al.
2010In Journal of Sleep Research, 19 (s2)
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Abstract :
[en] The Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which in the adult brain, regulates long-term potentiation and has been involved in the build up of the homeostatic sleep pressure in rodents. In humans, valine (val) to methionine (met) substitution in the 5’ pro-region of the BDNF protein is associated with poorer episodic memory. Neurons transfected with met-BDNF-Green Fluorescence Protein showed lower depolarization-induced secretion, while constitutive secretion is unchanged. Here, we hypothesized that the differences in BDNF release determined by this polymorphism would influence sleep-dependent memory consolidation and that in comparison with the met-carriers (val/met or met/met), val/val individuals would show higher memory performance after one night of sleep rather than an immediate retrieval session. This study was supported by FNRS-FRIA, the University of Liège, and the QEMF.
Disciplines :
Neurology
Genetics & genetic processes
Author, co-author :
Mascetti, Laura ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Foret, Ariane ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Matarazzo, Luca;  Université de Liège - ULiège > Centre de recherches du cyclotron
Muto, Vincenzo  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
DIDEBERG, Vinciane ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Influence of Brain-Derived Neurotrophic Factor val66met human polymorphism on declarative memory consolidation during sleep
Publication date :
15 September 2010
Event name :
20th Congress of the European Sleep Research Society
Event organizer :
European Sleep Research Society
Event place :
Lisbonne, Portugal
Event date :
14 - 18 septembre 2010
Audience :
International
Journal title :
Journal of Sleep Research
ISSN :
0962-1105
eISSN :
1365-2869
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
19
Issue :
s2
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 April 2011

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