[en] The Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which in the adult brain, regulates long-term potentiation and has been involved in the build up of the homeostatic sleep pressure in rodents. In humans, valine (val) to methionine (met) substitution in the 5’ pro-region of the BDNF protein is associated with poorer episodic memory. Neurons transfected with met-BDNF-Green Fluorescence Protein showed lower depolarization-induced secretion, while constitutive secretion is unchanged. Here, we hypothesized that the differences in BDNF release determined by this polymorphism would influence sleep-dependent memory consolidation and that in comparison with the met-carriers (val/met or met/met), val/val individuals would show higher memory performance after one night of sleep rather than an immediate retrieval session.
This study was supported by FNRS-FRIA, the University of Liège, and the QEMF.
Disciplines :
Neurology Genetics & genetic processes
Author, co-author :
Mascetti, Laura ; Université de Liège - ULiège > Centre de recherches du cyclotron
Foret, Ariane ; Université de Liège - ULiège > Centre de recherches du cyclotron
Matarazzo, Luca; Université de Liège - ULiège > Centre de recherches du cyclotron
Muto, Vincenzo ; Université de Liège - ULiège > Centre de recherches du cyclotron
DIDEBERG, Vinciane ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Influence of Brain-Derived Neurotrophic Factor val66met human polymorphism on declarative memory consolidation during sleep
Publication date :
15 September 2010
Event name :
20th Congress of the European Sleep Research Society