ORBi: Gusareva Elena - Different environmental influences on etiology of atopic diseases in European populations as a basis for study of geneenvironment interactions.

Reference : Different environmental influences on etiology of atopic diseases in European population...


	Document type :	Parts of books : Contribution to collective works
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/89580

Title :	Different environmental influences on etiology of atopic diseases in European populations as a basis for study of geneenvironment interactions.
Language :	English
Author, co-author :	Gusareva, Elena [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
	Belozorov, Aleksey [> >]
	Havelková, Helena [> >]
	Blažková, Hanna [> >]
	Kučera, H. [> >]
	Král, V. [> >]
	Savvo, A. [> >]
	Lipoldová, Marie [Institute of Molecular Genetics, Prague, Czech Republic > Molecular and Cellular Immunology > > >]
Publication date :	2008
Main document title :	Genetic Predisposition to Disease
Editor :	Torres, S. L.
	Marin, M. S.
Publisher :	2008 Nova Science Publishers, Inc.
Pages :	257-270
ISBN :	978-1-60456-835-6
Abstract :	[en] Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic diseases, including asthma, eczema, and allergic rhinitis. The development of these diseases is influenced by both genetic and environmental factors. Several loci and genes that control IgE level have been described in different chromosomal regions. Some of them have been detected in several populations, others only in one or a few populations. These differences might be caused by variations of genetic composition between populations, different lifestyles and/or by environmental variations in major allergens triggering development of atopic diseases. Thus, the environmental conditions may likely determine, which from the potential atopy-controlling genes will operate in a certain population. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukraine, representing two genetically not very distant populations, which live in different environmental conditions. The atopic patients from both countries displayed a higher reactivity to inhalant than to food allergens. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens for the atopic patients from Ukraine were allergens from dust mites Dermatophagoides pteronyssinus (38.5%), Dermatophagoides farinae (48.1%) and cat (44.2%). In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. More than 68% of the patients from the Czech Republic in comparison with less than 25% of the patients from Ukraine have been sensitized to cocksfoot, sweet vernal grass, timothy grass and cultivated rye (Bonferroni-corrected P values ranged from 0.0007 to 0.000000003). More than 50% and 60% of the patients from the Czech Republic but only 2% and 19.2% of the patients from Ukraine reacted to alder (corrected P < 0.00009) and birch (corrected P < 0.002), respectively. The higher sensitization to plant allergens of the patients from the Czech Republic was present in those with asthma and rhinitis, but not with dermatitis. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. Genetic analysis of atopic patients from these two countries will establish which geneloci control development of atopy under different environmental conditions.
Name of the research project :	Impact of genetic and environmental factors on development of atopy and allergic diseases in human populations
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/89580

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