Article (Scientific journals)
Acyclovir vs isoprinosine (immunovir) for suppression of recurrent genital herpes simplex infection.
Kinghorn, G. R.; Woolley, P. D.; Thin, R. N. et al.
1992In Genitourinary Medicine, 68 (5), p. 312-6
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Abstract :
[en] OBJECTIVE: To compare the efficacy and safety of oral acyclovir (400 mg twice daily) with oral isoprinosine (500 mg twice daily) in the suppression of recurrent genital herpes. DESIGN: Double-blind, double-dummy, randomised, controlled, parallel group trial. SETTING: 13 centres in UK, Belgium and Germany. SUBJECTS: 127 immunocompetent patients with frequently recurring genital herpes. MAIN OUTCOME MEASURES: Proportions of patients reporting recurrences, recurrence frequency, and mean duration of lesions during breakthrough recurrences in each treatment group during a 6 month treatment period; time to first recurrence during treatment and follow-up after treatment cessation. RESULTS: During treatment, acyclovir recipients showed significant differences (p < 0.05) when compared with isoprinosine recipients in terms of a lower proportion reporting recurrences (31% vs 96%), a reduced mean number of reported recurrences per patient (0.6 vs 3.6), a shorter mean duration of breakthrough lesions (6.4 days vs 8.2 days), and a longer mean time (standard error) to first recurrence (143.7 (9.1) days vs 40.5 (5.4) days. The mean time to first recurrence after treatment cessation did not differ between the two groups. As compared with placebo recipients, isoprinosine treated patients had an increased recurrence frequency (3.6 vs 2.5) during treatment, and a shorter time to first recurrence after treatment cessation. All treatments were well tolerated without serious adverse events or toxicity. CONCLUSIONS: Acyclovir is very effective in suppressing recurrent genital herpes and is clearly superior to isoprinosine which is not clinically useful in the dosage studied.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Kinghorn, G. R.
Woolley, P. D.
Thin, R. N.
De Maubeuge, J.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Engst, R.
Language :
English
Title :
Acyclovir vs isoprinosine (immunovir) for suppression of recurrent genital herpes simplex infection.
Publication date :
1992
Journal title :
Genitourinary Medicine
ISSN :
0266-4348
Publisher :
British Medical Association, London, United Kingdom
Volume :
68
Issue :
5
Pages :
312-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 April 2011

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