[en] The default mode network (DMN) is a set of brain regions that consistently shows higher activity at rest compared to tasks requiring sustained focused attention toward externally presented stimuli. The cognitive processes that the DMN possibly underlies remain a matter of debate. It has alternately been proposed that DMN activity reflects unfocused attention toward external stimuli or the occurrence of internally generated thoughts. The present study aimed at clarifying this issue by investigating the neural correlates of the various kinds of conscious experiences that can occur during task performance. Four classes of conscious experiences (i.e., being fully focused on the task, distractions by irrelevant sensations/perceptions, interfering thoughts related to the appraisal of the task, and mind-wandering) that varied along two dimensions (“task-relatedness” and “stimulus-dependency”) were sampled using thought-probes while the participants performed a go/no-go task. Analyses performed on the intervals preceding each probe according to the reported subjective experience revealed that both dimensions are relevant to explain activity in several regions of the DMN, namely the medial prefrontal cortex, posterior cingulate cortex/precuneus, and posterior inferior parietal lobe. Notably, an additive effect of the two dimensions was demonstrated for midline DMN regions. On the other hand, lateral temporal regions (also part of the DMN) were specifically related to stimulus-independent reports. These results suggest that midline DMN regions underlie cognitive processes that are active during both internal thoughts and external unfocused attention. They also strengthen the view that the DMN can be fractionated into different subcomponents and reveal the necessity to consider both the stimulus-dependent and the task-related dimensions of conscious experiences when studying the possible functional roles of the DMN.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Buckner RL, Andrews-Hanna JR, Schacter DL, (2008) The brain's default network: Anatomy, function, and relevance to disease. In: Kingstone A, Miller MB, editors. The Year in Cognitive Neuroscience 2008 Malden Blackwell Publishing pp. 1-38.
Raichle ME, Snyder AZ, (2007) A default mode of brain function: a brief history of an evolving idea. Neuroimage 37: 1083-1090.
Shulman GL, Fiez JA, Corbetta M, Buckner RL, Miezin FM, et al. (1997) Common blood flow changes across visual tasks: II.: Decreases in cerebral cortex. Journal of Cognitive Neuroscience 9: 648-663.
Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, et al. (2001) Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Research Bulletin 54: 287-298.
Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, et al. (2001) A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America 98: 676-682.
Greicius MD, Krasnow B, Reiss AL, Menon V, (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences of the United States of America 100: 253-258.
Binder JR, Frost JA, Hammeke TA, Bellgowan PS, Rao SM, et al. (1999) Conceptual processing during the conscious resting state. A functional MRI study. Journal of Cognitive Neuroscience 11: 80-95.
Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, et al. (2007) Wandering Minds: The Default Network and Stimulus-Independent Thought. Science 315: 393-395.
Gilbert SJ, Dumontheil I, Simons JS, Frith CD, Burgess PW, (2007) Comment on "Wandering minds: the default network and stimulus-independent thought". Science 317: 43b.
Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, et al. (2007) Response to Comment on "Wandering Minds: The Default Network and Stimulus-Independent Thought". Science 317: 43c.
Andrews-Hanna JR, Reidler JS, Huang C, Buckner RL, (2010) Evidence for the default network's role in spontaneous cognition. Journal of Neurophysiology 104: 322-335.
Buckner RL, Carroll DC, (2007) Self-projection and the brain. Trends in Cognitive Sciences 11: 49-57.
Buckner RL, Vincent JL, (2007) Unrest at rest: default activity and spontaneous network correlations. Neuroimage 37: 1091-1096.
McKiernan KA, D'Angelo BR, Kaufman JN, Binder JR, (2006) Interrupting the "stream of consciousness": an fMRI investigation. Neuroimage 29: 1185-1191.
McGuire PK, Paulesu E, Frackowiak RS, Frith CD, (1996) Brain activity during stimulus independent thought. Neuroreport 7: 2095-2099.
Christoff K, Gordon AM, Smallwood J, Schooler JW, Smith R, (2009) Experience sampling during fMRI reveals default network and executive system contributions to mind wandering. Proceedings of the National Academy of Sciences of the United States of America 106: 8719-8724.
Kim H, Daselaar SM, Cabeza R, (2010) Overlapping brain activity between episodic memory encoding and retrieval: roles of the task-positive and task-negative networks. Neuroimage 49: 1045-1054.
Kim H, (2010) Dissociating the roles of the default-mode, dorsal, and ventral networks in episodic memory retrieval. Neuroimage 50: 1648-1657.
Schacter DL, Addis DR, Buckner RL, (2007) Remembering the past to imagine the future: the prospective brain. Nature Reviews Neuroscience 8: 657-661.
Schilbach L, Eickhoff SB, Rotarska-Jagiela A, Fink GR, Vogeley K, (2008) Minds at rest? Social cognition as the default mode of cognizing and its putative relationship to the "default system" of the brain. Consciousness and Cognition: An International Journal 17: 457-467.
Spreng RN, Mar RA, Kim AS, (2009) The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis. Journal of Cognitive Neuroscience 21: 489-510.
Spreng RN, Grady CL, (2010) Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network. Journal of Cognitive Neuroscience 22: 1112-1123.
Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, et al. (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America 102: 9673-9678.
Fox MD, Raichle ME, (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Reviews Neuroscience 8: 700-711.
Hahn B, Ross TJ, Stein EA, (2007) Cingulate activation increases dynamically with response speed under stimulus unpredictability. Cerebral cortex 17: 1664-1671.
Anticevic A, Repovs G, Shulman GL, Barch DM, (2010) When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage 49: 2638-2648.
Gilbert SJ, Simons JS, Frith CD, Burgess PW, (2006) Performance-related activity in medial rostral prefrontal cortex (area 10) during low-demand tasks. Journal of Experimental Psychology: Human Perception & Performance 32: 45-58.
Gilbert SJ, Frith CD, Burgess PW, (2005) Involvement of rostral prefrontal cortex in selection between stimulus-oriented and stimulus-independent thought. European Journal of Neuroscience 21: 1423-1431.
Unsworth N, Redick TS, Lakey CE, Young DL, (2010) Lapses in sustained attention and their relation to executive control and fluid abilities: An individual differences investigation. Intelligence 38: 111-122.
Forster S, Lavie N, (2008) Failures to ignore entirely irrelevant distractors: The role of load. Journal of Experimental Psychology: Applied 14: 73-83.
Lustig C, Hasher L, Tonev ST, (2001) Inhibitory control over the present and the past. European Journal of Cognitive Psychology 13: 107-122.
Gusnard DA, Raichle ME, (2001) Searching for a baseline: functional imaging and the resting human brain. Nature Reviews Neuroscience 2: 685-694.
Mayer JS, Roebroeck A, Maurer K, Linden DE, (2010) Specialization in the default mode: Task-induced brain deactivations dissociate between visual working memory and attention. Human Brain Mapping 31: 126-139.
Vincent JL, Kahn I, Snyder AZ, Raichle ME, Buckner RL, (2008) Evidence for a frontoparietal control system revealed by intrinsic functional connectivity. Journal of Neurophysiology 100: 3328-3342.
Gilbert SJ, Williamson ID, Dumontheil I, Simons JS, Frith CD, et al. (2007) Distinct regions of medial rostral prefrontal cortex supporting social and nonsocial functions. Social Cognitive and Affective Neuroscience 2: 217-226.
Smallwood J, Baracaia SF, Lowe M, Obonsawin M, (2003) Task unrelated thought whilst encoding information. Consciousness and Cognition: An International Journal 12: 452-484.
Smallwood J, Davies JB, Heim D, Finnigan F, Sudberry M, et al. (2004) Subjective experience and the attentional lapse: Task engagement and disengagement during sustained attention. Consciousness and Cognition: An International Journal 13: 657-690.
Matthews G, Joyner L, Gililand K, Campbell SE, Faulconner S, (1999) Validation of a comprehensive stress state questionnaire: Towards a state Big three? In: Mervielde I, Deary IJ, De Fruyt F, Ostendorf F, editors. Handbook of coping: Theory, research and applications Tilburg Netherlands Tilburg University Press pp. 333-350.
Dumontheil I, Gilbert SJ, Frith CD, Burgess PW, (2010) Recruitment of lateral rostral prefrontal cortex in spontaneous and task-related thoughts. Quarterly Journal of Experimental Psychology 63: 1740-1756.
Vanhaudenhuyse A, Demertzi A, Schabus M, Noirhomme Q, Bredart S, et al. (2011) Two distinct neuronal networks mediate the awareness of environment and of self. Journal of Cognitive Neuroscience 23: 570-578.
Robertson IH, Manly T, Andrade J, Baddeley BT, Yiend J, (1997) 'Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects. Neuropsychologia 35: 747-758.
Giambra LM, (1995) A laboratory method for investigating influences on switching attention to task-unrelated imagery and thought. Consciousness and Cognition: An International Journal 4: 1-21.
Smallwood J, McSpadden M, Schooler JW, (2007) The lights are on but no one's home: Meta-awareness and the decoupling of attention when the mind wanders. Psychonomic Bulletin & Review 14: 527-533.
McVay JC, Kane MJ, (2009) Conducting the train of thought: Working memory capacity, goal neglect, and mind wandering in an executive-control task. Journal of Experimental Psychology: Learning, Memory, and Cognition 35: 196-204.
Smallwood J, Beach E, Schooler JW, Handy TC, (2008) Going AWOL in the brain: Mind wandering reduces cortical analysis of external events. Journal of Cognitive Neuroscience 20: 458-469.
Kam JW, Dao E, Farley J, Fitzpatrick K, Smallwood J, et al. (2011) Slow fluctuations in attentional control of sensory cortex. Journal of Cognitive Neuroscience 23: 460-470.
Smallwood J, McSpadden M, Luus B, Schooler JW, (2008) Segmenting the stream of consciousness: The psychological correlates of temporal structures in the time series data of a continuous performance task. Brain and Cognition 66: 50-56.
Nichols T, Brett M, Andersson J, Wager T, Poline J-B, (2005) Valid conjunction inference with the minimum statistic. Neuroimage 25: 653-660.
Toro R, Fox PT, Paus T, (2008) Functional coactivation map of the human brain. Cerebral Cortex 18: 2553-2559.
Weissman DH, Roberts KC, Visscher KM, Woldorff MG, (2006) The neural bases of momentary lapses in attention. Nature Neuroscience 9: 971-978.
Walther S, Goya-Maldonado R, Stippich C, Weisbrod M, Kaiser S, (2010) A supramodal network for response inhibition. Neuroreport 21: 191-195.
Stawarczyk D, Majerus S, Maj M, Van Der Linden M, D'Argembeau A, (In Press) Mind-wandering: phenomenology and function as assessed with a novel experience sampling method. Acta Psychologica.
Cunningham S, Scerbo MW, Freeman FG, (2000) The electrocortical correlates of daydreaming during vigilance tasks. Journal of Mental Imagery 24: 61-72.
Goldberg II, Harel M, Malach R, (2006) When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50: 329-339.
Gusnard DA, Akbudak E, Shulman GL, Raichle ME, (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America 98: 4259-4264.
Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, et al. (2006) Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 31: 440-457.
Schmitz TW, Johnson SC, (2007) Relevance to self: A brief review and framework of neural systems underlying appraisal. Neuroscience and Biobehavioral Reviews 31: 585-596.
D'Argembeau A, Collette F, Van der Linden M, Laureys S, Del Fiore G, et al. (2005) Self-referential reflective activity and its relationship with rest: a PET study. Neuroimage 25: 616-624.
D'Argembeau A, Stawarczyk D, Majerus S, Collette F, Van der Linden M, et al. (2010) Modulation of medial prefrontal and inferior parietal cortices when thinking about past, present, and future selves. Social Neuroscience 5: 187-200.
Kelley W, Macrae C, Wyland C, Caglar S, Inati S, et al. (2002) Finding the self?: An event-related fMRI study. Journal of Cognitive Neuroscience 14: 785-794.
Schneider F, Bermpohl F, Heinzel A, Rotte M, Walter M, et al. (2008) The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures. Neuroscience 157: 120-131.
Singer JL, (1998) Daydreams, the stream of consciousness, and self-representations. In: Bornstein RF, Masling JM, editors. Empirical perspectives on the psychoanalytic unconscious Washington, DC American Psychological Association pp. 141-186.
Klinger E, Barta SG, Maxeiner ME, (1980) Motivational correlates of thought content frequency and commitment. Journal of Personality and Social Psychology 39: 1222-1237.
Gold SR, Reilly JP, (1985) Daydreaming, current concerns and personality. Imagination, Cognition and Personality 5: 117-125.
Cheyne JA, Solman GJF, Carriere JSA, Smilek D, (2009) Anatomy of an error: A bidirectional state model of task engagement/disengagement and attention-related errors. Cognition 111: 98-113.
Sonuga-Barke EJ, Castellanos FX, (2007) Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neuroscience and Biobehavioral Reviews 31: 977-986.
Raichle ME, (2006) Neuroscience. The brain's dark energy. [Erratum appears in Science. 2007 Jan 12;315(5809):187]. Science 314: 1249-1250.
Christoff K, Gordon A, Smith R, (In Press) The role of spontaneous thought in human cognition. In: Vartanian O, Mangel D, editors. Neuroscience of decision making Hove, NY Psychology Press.
Bar M, (2007) The proactive brain: Using analogies and associations to generate predictions. Trends in Cognitive Sciences 11: 280-289.
Bar M, (2009) The proactive brain: memory for predictions. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences 364: 1235-1243.
Burgess PW, Dumontheil I, Gilbert SJ, (2007) The gateway hypothesis of rostral prefrontal cortex (area 10) function. Trends in Cognitive Sciences 11: 290-298.
Binder JR, Desai RH, Graves WW, Conant LL, (2009) Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cerebral Cortex 19: 2767-2796.
Svoboda E, McKinnon MC, Levine B, (2006) The functional neuroanatomy of autobiographical memory: A meta-analysis. Neuropsychologia 44: 2189-2208.
Burianova H, McIntosh AR, Grady CL, (2010) A common functional brain network for autobiographical, episodic, and semantic memory retrieval. Neuroimage 49: 865-874.
Smith EE, Jonides J, (1999) Storage and executive processes in the frontal lobes. Science 283: 1657-1661.
Duncan J, Owen AM, (2000) Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends in Neurosciences 23: 475-483.
McVay JC, Kane MJ, (2010) Does mind wandering reflect executive function or executive failure? Comment on Smallwood and Schooler (2006) and Watkins (2008). Psychological Bulletin 136: 188-197.
Mitchell JP, Heatherton TF, Kelley WM, Wyland CL, Wegner DM, et al. (2007) Separating sustained from transient aspects of cognitive control during thought suppression. Psychological Science 18: 292-297.
Teasdale JD, Dritschel BH, Taylor MJ, Proctor L, Lloyd CA, et al. (1995) Stimulus-independent thought depends on central executive resources. Memory & Cognition 23: 551-559.
Teasdale JD, Proctor L, Lloyd CA, Baddeley AD, (1993) Working memory and stimulus-independent thought: Effects of memory load and presentation rate. European Journal of Cognitive Psychology 5: 417-433.
Christoff K, Keramatian K, Gordon AM, Smith R, Madler B, (2009) Prefrontal organization of cognitive control according to levels of abstraction. Brain Research 1286: 94-105.
Spreng RN, Stevens WD, Chamberlain JP, Gilmore AW, Schacter DL, (2010) Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition. Neuroimage 53: 303-317.
Corbetta M, Shulman GL, (2002) Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience 3: 201-215.
Majerus S, Poncelet M, Van der Linden M, Albouy G, Salmon E, et al. (2006) The left intraparietal sulcus and verbal short-term memory: focus of attention or serial order? Neuroimage 32: 880-891.
Majerus S, Bastin C, Poncelet M, Van der Linden M, Salmon E, et al. (2007) Short-term memory and the left intraparietal sulcus: focus of attention? Further evidence from a face short-term memory paradigm. Neuroimage 35: 353-367.
Dosenbach NUF, Fair DA, Miezin FM, Cohen AL, Wenger KK, et al. (2007) Distinct brain networks for adaptive and stable task control in humans. Proceedings of the National Academy of Sciences of the United States of America 104: 11073-11078.
Nee DE, Wager TD, John J, (2007) Interference resolution: Insights from a meta-analysis of neuroimaging tasks. Cognitive, Affective & Behavioral Neuroscience 7: 1-17.
Simmonds DJ, Pekar JJ, Mostofsky SH, (2008) Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia 46: 224-232.
Buchsbaum BR, Greer S, Chang W-L, Berman KF, (2005) Meta-analysis of neuroimaging studies of the Wisconsin card-sorting task and component processes. Human Brain Mapping 25: 35-45.
Lutz A, Thompson E, (2003) Neurophenomenology: Integrating Subjective Experience and Brain Dynamics in the Neuroscience of Consciousness. Journal of Consciousness Studies 10: 31-52.
Benoit RG, Gilbert SJ, Volle E, Burgess PW, (2010) When I think about me and simulate you: medial rostral prefrontal cortex and self-referential processes. Neuroimage 50: 1340-1349.
Singer JL, (1993) Experimental studies of ongoing conscious experience. Ciba Foundation Symposium 174: 100-122.
Klinger E, (2009) Daydreaming and fantasizing: Thought flow and motivation. In: Markman KD, Klein WMP, Suhr JA, editors. Handbook of imagination and mental simulation New York, NY Psychology Press pp. 225-239.